{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:34:10Z","timestamp":1791401650438,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T00:00:00Z","timestamp":1354579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold> Wheat protein derivatives are used in a variety of products worldwide. Gluten is commercially used \u2018as is' or with modifications such as hydrolysis, which is carried out to overcome its insolubility. Several cases of contact urticaria following exposure to hydrolysed wheat protein (HWP) in cosmetics or of anaphylaxis caused by deamidated gluten in food or non\u2010food products have been described.<\/jats:p><jats:p><jats:bold>Objectives<\/jats:bold> To evaluate the types of HWP that have higher allergenicity for percutaneous sensitization.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> We enrolled 7 patients with wheat\u2010dependent exercise\u2010induced anaphylaxis who had been sensitized to HWP primarily through the percutaneous and\/or the rhinoconjunctival route by using facial soap containing HWP. Reaction to wheat proteins was confirmed by IgE immunoblotting and basophil CD203c expression with six HWP variants.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> The IgE of all the patients reacted to HWPs composed of large polypeptide aggregates. High molecular weight (MW) HWPs were also found to induce significant enhancement of basophil CD203c expression.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> HWPs composed of large polypeptide aggregates possibly induce sensitization to a greater degree than lower\u2010MW HWPs. Basophil surface CD203c expression is useful for evaluating the allergenicity of HWPs.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02168.x","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T18:13:34Z","timestamp":1354644814000},"page":"86-93","source":"Crossref","is-referenced-by-count":37,"title":["Higher allergenicity of high molecular weight hydrolysed wheat protein in cosmetics for percutaneous sensitization"],"prefix":"10.1111","volume":"68","author":[{"given":"Yuko","family":"Chinuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Dekio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuho","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishin","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.03.004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90210-F"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.09-RAI-0125"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04601.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04329.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01504.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.035"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01917.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.049"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02213.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04858.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1993.1313"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000126061"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282204"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00830.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200306000-00009"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.08-OA-0023"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000312126"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118515"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.014"},{"key":"e_1_2_6_22_2","unstructured":"Information provided by the Japanese Society of Allergology 2011.http:\/\/www.jsaweb.jp\/modules\/news_topics\/index.php?page. 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