{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:30:05Z","timestamp":1771014605788,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold>The currently used patch test concentration for formaldehyde is 1.0% (wt\/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold>To validate earlier patch test results for comparison of 1% (wt\/vol) and 2% (wt\/vol) formaldehyde in water, and to investigate co\u2010reactivity with quaternium\u201015.<\/jats:p><jats:p><jats:bold>Materials and methods.<\/jats:bold>In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt\/vol) (0.60 mg\/cm<jats:sup>2<\/jats:sup>) and 1.0% (wt\/vol) (0.30 mg\/cm<jats:sup>2<\/jats:sup>) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold>Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, <jats:italic>p<\/jats:italic> &lt; 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium\u201015\u2010positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold>On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt\/vol) in water formaldehyde should be used in routine patch testing in the baseline series.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02169.x","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T04:39:15Z","timestamp":1349411955000},"page":"50-53","source":"Crossref","is-referenced-by-count":29,"title":["Patch testing with 2.0% (0.60 mg\/cm<sup>2<\/sup>) formaldehyde instead of 1.0% (0.30 mg\/cm<sup>2<\/sup>) detects significantly more contact allergy"],"prefix":"10.1111","volume":"68","author":[{"given":"Ann","family":"Pont\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristiina","family":"Aalto\u2010Korte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe J.","family":"Le Coz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard I.","family":"Maibach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archderm.1966.01600260078009","article-title":"Formaldehyde allergy. Incidence and patch test problems.","volume":"94","author":"Epstein E","year":"1966","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05630.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01797.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0925"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10151.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01292.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01098.x"},{"key":"e_1_2_5_9_2","first-page":"287","article-title":"Terminology of contact dermatitis.","volume":"50","author":"Wilkinson D S","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)94256-0"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb02072.x"},{"key":"e_1_2_5_12_2","first-page":"154","article-title":"Late patch\u2010test reactions to budesonide need not be a sign of sensitization induced by the test procedure.","volume":"14","author":"Isaksson M","year":"2003","journal-title":"Am J Contact Dermat"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00705.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01197.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2012.02169.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2012.02169.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T19:16:14Z","timestamp":1697656574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2012.02169.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,5]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1600-0536.2012.02169.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2012.02169.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,5]]}}}