{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:49:25Z","timestamp":1772160565882,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T00:00:00Z","timestamp":1349827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>\n                    <jats:bold>Background.<\/jats:bold>\n                    It is unclear whether the respiratory tract is involved in eliciting or aggravating eczematous lesions in patients with vesicular hand eczema.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives.<\/jats:bold>\n                    To investigate the effect of inhalation of house dust mite (HDM) on vesicular hand eczema.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods.<\/jats:bold>\n                    Eighteen patients with vesicular hand eczema and HDM allergy received inhalation challenges with four concentrations of HDM in a randomized, double\u2010blind, placebo\u2010controlled, cross\u2010over study. Early asthmatic reactions and late asthmatic reactions were defined as a placebo\u2010corrected fall of 15% or more from baseline of forced expiratory volume in 1 second. Hand eczema was scored according to the Dyshidrotic Eczema Area and Severity Index (DASI) at baseline, and 1, 6, 24 and 48 hr.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    The median DASI increased significantly as compared with baseline at 6 and 48 hr after HDM inhalation. This increase was significantly different between the provocations at 6 hr. The median vesicles score increased significantly from baseline at 24 and 48 hr. Patients with a placebo\u2010corrected increase in the number of vesicles at 24 hr and 48 hr had significantly more often late asthmatic reactions than those without an increase in the number of vesicles. Patients with a placebo\u2010corrected increase of the DASI score at 24 hours had as a group a higher mean total IgE level than those without an increase of the DASI score.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    Hand eczema increased significantly more after HDM provocation than after placebo provocation. An increase in the number of vesicles was preceded by late asthmatic reactions. The group patients with an increase of hand eczema tended to have a higher mean total IgE level.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02172.x","type":"journal-article","created":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T03:06:24Z","timestamp":1349838384000},"page":"76-85","source":"Crossref","is-referenced-by-count":13,"title":["Increase in vesicular hand eczema after house dust mite inhalation provocation: a double\u2010blind, placebo\u2010controlled, cross\u2010over study"],"prefix":"10.1111","volume":"68","author":[{"given":"Marie Louise A.","family":"Schuttelaar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter Jan","family":"Coenraads","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneke","family":"Huizinga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G.","family":"De Monchy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin M.","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb00862.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310007184"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.056002152.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03666.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126791"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00403.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70259-2"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01256.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.05.013"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018127"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08530.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.5.7952550"},{"key":"e_1_2_7_14_2","first-page":"373","article-title":"Bronchoalveolar eosinophilia during allergen\u2010induced late asthmatic reactions.","volume":"131","author":"De Monchy J G","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1183\/09031936.93.06060840","article-title":"Dynamics of eosinophil infiltration in the bronchial mucosa before and after the late asthmatic reaction.","volume":"6","author":"Aalbers R","year":"1993","journal-title":"Eur Respir J"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09463.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2982"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2012.02172.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2012.02172.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:38:00Z","timestamp":1697611080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2012.02172.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,10]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1600-0536.2012.02172.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2012.02172.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717962092.793466058","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717962092.793465125","asserted-by":"object"}]},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,10]]}}}