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Direct immunofluo\u2010rescence testing may be useful in supplementing the histopathologic evaluation. Detection of immunoglobulins, complement, or both at the basement membrane zone in lesional skin by immunofluorescence occurs in approximately half of cases; a negative study does not preclude the diagnosis of NLE syndrome. Clinical and serologic evaluation of both the infant and the mother are important in establishing a diagnosis of NLE syndrome, particularly when histopathologic findings are subtle.<\/jats:p>","DOI":"10.1111\/j.1600-0560.1991.tb01545.x","type":"journal-article","created":{"date-parts":[[2006,4,29]],"date-time":"2006-04-29T10:16:51Z","timestamp":1146305811000},"page":"333-338","source":"Crossref","is-referenced-by-count":16,"title":["Neonatal lupus erythematosus syndrome"],"prefix":"10.1111","volume":"18","author":[{"given":"B.","family":"Maynard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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