{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:55:00Z","timestamp":1790661300750,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Keratinocyte damage and lichenoid\u2010interface reaction are the two major pathologic findings in lichen planus (LP). Matrix metalloproteinases (MMPs) are proteinases that participate in extracellular matrix (ECM) degradation and may play an important role in basal membrane (BM) damage in LP. Fibronectin (FN) mediates a variety of cellular interactions with ECM and plays important roles in cell adhesion, migration, growth and differentiation.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To determine MMP\u20102, MMP\u20103, MMP\u20109 and FN expressions in LP and discuss the possible associations.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> Skin biopsy samples of 55 patients with LP and 11 normal skin were investigated. Five discoid lupus erythematosus (DLE) and 5 chronic dermatitis (CD) samples were also examined for comparison. Immunochemical stainings were performed for MMP\u20102, MMP\u20103, MMP\u20109 and fibronectin.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Weak or absent expressions of MMP\u20102 and MMP\u20103 in epidermis; and dense MMP\u20109 expression in dermal inflammatory infiltrate cells were detected in LP. FN expression was lost in epidermal basal layer and papillary dermis.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Loss of MMP\u20102, MMP\u20103 and FN in LP can be explained with the destruction of the epidermal basal layer. Similar expressions of MMP\u20102 and MMP\u20103 both in LP and DLE implied that these MMPs may be involved in the pathogenesis of interface dermatitis.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00456.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T18:47:04Z","timestamp":1155062824000},"page":"545-550","source":"Crossref","is-referenced-by-count":29,"title":["Expression of matrix metalloproteinases (MMP\u20102, MMP\u20103, and MMP\u20109) and fibronectin in lichen planus"],"prefix":"10.1111","volume":"33","author":[{"given":"Kamer","family":"Gunduz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyker","family":"Demireli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isil","family":"Inanir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalan","family":"Nese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"561","volume-title":"Dermatology in general medicine","author":"Daoud MS","year":"1999"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00059"},{"key":"e_1_2_6_5_2","first-page":"166","volume-title":"Lever's histopathology of the skin","author":"Toussaint S","year":"1997"},{"key":"e_1_2_6_6_2","first-page":"1091","article-title":"Altered expression of basement membrane proteins and their integrin receptors in lichen planus: possible pathogenetic role of gelatinases A and B","volume":"74","author":"Giannelli G","year":"1996","journal-title":"Lab Invest"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.372"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.280203.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12313384"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1242\/jcs.109.3.631","article-title":"Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium","volume":"109","author":"Pullan S","year":"1996","journal-title":"J Cell Sci"},{"key":"e_1_2_6_11_2","first-page":"1945","article-title":"Spectrum of extracellular matrix degrading enzymes in normal and malignant T lymphocytes","volume":"19","author":"Hauzenberger D","year":"1999","journal-title":"Anticancer Res"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00456.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00456.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T18:11:29Z","timestamp":1695665489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00456.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00456.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00456.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}