{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:34:53Z","timestamp":1761510893196},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The diagnosis of tuberculoid leprosy is often difficult on hematoxylin and eosin (H&amp;E) due to the absence of demonstrable nerve destruction. This study evaluates the utility of S\u2010100 staining in identifying nerve fragmentation and differentiation of tuberculoid leprosy from other cutaneous granulomatous diseases.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Fifty cases of leprosy including 38 borderline tuberculoid (BT), two tuberculoid (TT), and 10 indeterminate leprosy (IL) were studied. Eleven controls of non\u2010lepromatous cutaneous granulomatous lesions were included. S\u2010100 was used for identifying the following dermal nerve patterns: infiltrated (A), fragmented (B), absent (C), and intact (D) nerves.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> On H&amp;E, only 18\/38 (47.4%) BT cases and 1\/2 (50%) TT cases revealed neural inflammation. On S\u2010100 staining of BT cases, 28\/38 (73.7%) showed pattern B followed by patterns C and A in 8\/38 (21.1%) and 2\/38 (5.3%) cases, respectively. Both the TT cases showed pattern B. Only intact nerves (D) were seen in all the control cases. S\u2010100 identified nerve damage in 4\/10 (40%) IL cases. The patterns A, B, and C had sensitivity, specificity, and positive and negative predictive values of 100% in diagnosing tuberculoid (BT\u2003+\u2003TT) leprosy.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> S\u2010100 is superior to H&amp;E in identifying nerve fragmentation (p\u2003&lt;\u20030.01). It also aids the differential diagnosis of tuberculoid leprosy.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00457.x","type":"journal-article","created":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T20:47:15Z","timestamp":1149022035000},"page":"482-486","source":"Crossref","is-referenced-by-count":12,"title":["S\u2010100 as a useful auxiliary diagnostic aid in tuberculoid leprosy"],"prefix":"10.1111","volume":"33","author":[{"given":"Sanjeev Kumar","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonu","family":"Nigam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish K.","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,10]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"239","volume-title":"Park's textbook of preventive and social medicine","author":"Park K","year":"2001"},{"key":"e_1_2_5_3_2","first-page":"1","article-title":"Role of S\u2010100 staining in differentiating leprosy from other granulomatous diseases of the skin","volume":"67","author":"Thomas MM","year":"1999","journal-title":"Int J Lepr"},{"key":"e_1_2_5_4_2","first-page":"255","article-title":"Classification of leprosy according to immunity: A five group system","volume":"34","author":"Ridley DS","year":"1966","journal-title":"Int J Lepr"},{"key":"e_1_2_5_5_2","first-page":"338","article-title":"S\u2010100 protein and immunoperoxidase technique as an aid in the histopathologic diagnosis of leprosy","volume":"55","author":"Fleury RN","year":"1987","journal-title":"Int J Lepr"},{"key":"e_1_2_5_6_2","first-page":"263","article-title":"An evaluation of the S\u2010100 stain in the histological diagnosis of tuberculoid leprosy and other granulomatous dermatoses","volume":"62","author":"Singh N","year":"1994","journal-title":"Int J Lepr"},{"key":"e_1_2_5_7_2","first-page":"392","article-title":"Role of S\u2010100 protein as a marker for Schwann cells in the diagnosis of tuberculoid leprosy","volume":"58","author":"Job CK","year":"1990","journal-title":"Int J Lepr"},{"key":"e_1_2_5_8_2","first-page":"504","volume":"21","author":"International Lep. Congress, Madrid","year":"1953","journal-title":"Int J Lep"},{"key":"e_1_2_5_9_2","first-page":"32","volume-title":"Skin biopsy in leprosy.","author":"Ridley DS","year":"1977"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00157.x"},{"key":"e_1_2_5_11_2","first-page":"755","article-title":"Significance and interpretation of nerve changes in skin biopsies when present in association with common dermatological conditions","volume":"52","author":"Jacob M","year":"1984","journal-title":"Int J Lepr"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00457.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00457.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:56:35Z","timestamp":1696992995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00457.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00457.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00457.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}