{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:13:52Z","timestamp":1766268832093},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T00:00:00Z","timestamp":1152489600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Introduction:\u2002<\/jats:bold> Drugs may be an important cause of atypical lymphocytic infiltration. Oftentimes, these infiltrates are in the context of pseudolymphomata. We report a patient who developed lymphocytoma cutis temporally associated with initiation of fluoxetine therapy that later went on to develop cutaneous marginal zone B\u2010cell lymphoma. The response of peripheral blood lymphocytes to fluoxetine and other drugs was examined in an attempt to ascertain the potential role for drugs in the propagation of these infiltrates.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> Routine light microscopic analysis and phenotypic studies were performed on tissue obtained from a skin biopsy. Lymphocyte mitogenic studies were carried out using increasing concentrations of fluoxetine, bupropion, and two anticonvulsants.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> An initial biopsy was consistent with lymphocytoma cutis. The patient stopped fluoxetine associated with lesional regression. The lesions recurred despite being off fluoxetine; a repeat biopsy was compatible with marginal zone lymphoma. Lymphocyte proliferation assays revealed a suppressive effect on T\u2010lymphocyte proliferation at physiologic concentrations. Other tested drugs did not have a similar suppressive effect.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Fluoxetine may be associated with pseudolymphomata and marginal zone lymphoma. The inhibitory effects on T\u2010lymphocyte function and more specifically T\u2010suppressor function may lead to excessive antigen\u2010driven B\u2010cell proliferation.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00475.x","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T18:10:30Z","timestamp":1152555030000},"page":"522-528","source":"Crossref","is-referenced-by-count":25,"title":["Cutaneous marginal zone B\u2010cell lymphoma in the setting of fluoxetine therapy: a hypothesis regarding pathogenesis based on <i>in vitro<\/i> suppression of T\u2010cell\u2010proliferative response"],"prefix":"10.1111","volume":"33","author":[{"suffix":"Jr","given":"Thomas 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