{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:47:28Z","timestamp":1776952048831,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Squamous cell carcinoma in an area of chronic ulceration is a well\u2010documented phenomenon. However, its occurrence arising <jats:italic>de novo<\/jats:italic> in an area of necrobiosis lipoidica is rare.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> We report a case in a 53\u2010year\u2010old female who presented with a 2 month history of an erythematous nodule occurring in a plaque of necrobiosis lipoidica on the medical aspect of the right lower leg. She had a background of poorly controlled Type 1 diabetes.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Histopathological findings revealed a well\u2010differentiated squamous cell carcinoma overlying an area of necrobiosis lipoidica. Treatment was by excision and split\u2010thickness skin graft.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Clinicians should be aware of malignant transformation within a plaque of necrobiosis lipoidica. Early detection will allow conservative treatment.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00487.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T18:47:04Z","timestamp":1155062824000},"page":"581-583","source":"Crossref","is-referenced-by-count":32,"title":["Squamous cell carcinoma arising in an area of long\u2010standing necrobiosis lipoidica"],"prefix":"10.1111","volume":"33","author":[{"given":"Cathy","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Tschuchnigg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb01411.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1978.tb00219.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-965.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02663.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00444.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00452.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00715.x"},{"key":"e_1_2_5_9_2","first-page":"461","article-title":"Carcinoma cuniculatum arising in necrobiosis lipoidica","volume":"118","author":"Porneuf M","year":"1991","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000248001"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1987.tb00321.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1985.01660010028008"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1966.01600210008002"},{"key":"e_1_2_5_14_2","first-page":"26","article-title":"Squamous cell carcinoma in a plaque of necrobiosis lipoidica diabeticorum","volume":"43","author":"Pavithran K","year":"1998","journal-title":"Indian J Dermatol"},{"key":"e_1_2_5_15_2","first-page":"73","article-title":"Squamous cell carcinoma arising on cutaneous discoid lupus erythematosus. 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