{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:45:48Z","timestamp":1762865148594},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Cutaneous lymphomas co\u2010expressing CD56 and CD30 are very rare. They share a clinicopathological overlap with natural killer\u2010 (NK)\/T\u2010cell lymphomas and anaplastic large\u2010cell lymphomas (ALCLs), two entities with widely disparate clinical behavior.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We present a case of an immunocompetent 57\u2010year\u2010old Caucasian woman with a rapidly growing, angiodestructive and neuroinvasive primary cutaneous ALCL (PCALCL). The neoplastic population of large anaplastic CD30<jats:sup>+<\/jats:sup> and CD56<jats:sup>+<\/jats:sup> T cells was masked by a massive admixture of histiocytes and neutrophils. The partially ulcerated and pus\u2010secreting tumor involved the forehead and scalp and was assessed as clinical stage IAE.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> After chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone), the patient achieved a complete remission. Additionally, high\u2010dose chemotherapy with autologous peripheral blood stem\u2010cell transplantation was administered as a consolidation of complete remission, in which she has remained for 6 years.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This is the first CD30<jats:sup>+<\/jats:sup> and CD56<jats:sup>+<\/jats:sup> primary skin lymphoma to be reported on the head. The presented case carries a remarkable combination of clinicopathological features of PCALCL and NK\u2010\/T\u2010cell lymphoma.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00488.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T18:47:04Z","timestamp":1155062824000},"page":"584-589","source":"Crossref","is-referenced-by-count":21,"title":["Primary cutaneous histiocyte and neutrophil\u2010rich CD30<sup>+<\/sup> and CD56<sup>+<\/sup> anaplastic large\u2010cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman"],"prefix":"10.1111","volume":"33","author":[{"given":"Ludmila","family":"Boudova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry V.","family":"Kazakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Jindra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radek","family":"Sima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Vanecek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilem","family":"Kuntscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vozobulova","family":"Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Bouda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Michal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"World health organization classification of tumours","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.12.3653"},{"key":"e_1_2_6_5_2","first-page":"2993","article-title":"Prognostic significance of CD56 expression for ALK\u2010positive and ALK\u2010negative anaplastic large\u2010cell lymphoma of T\/null cell phenotype","volume":"96","author":"Suzuki R","year":"2000","journal-title":"Blood"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027008392.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92814-A"},{"key":"e_1_2_6_9_2","first-page":"17","article-title":"Genotyping of Epstein\u2013Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue. 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