{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:32:25Z","timestamp":1791325945716,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T00:00:00Z","timestamp":1157500800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Merkel cell carcinoma (MCC) is an aggressive tumor of cutaneous neuroendocrine cells with a reported 13\u2010fold increased incidence in immunocompromised patients, raising the possibility that it is driven by an oncogenic virus. Additionally, Merkel cell hyperplasia is seen in the Epstein\u2013Barr virus (EBV)\u2010driven process oral hairy leukoplakia, and EBV is known to be involved in the pathogenesis of several other malignancies.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> We tested the hypothesis that EBV is involved in MCC.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We employed EBV\u2010encoded RNA <jats:italic>in situ<\/jats:italic> hybridization (ISH), lytic EBV ISH, latent membrane protein 1 immunohistochemistry, and BamH1Z leftward reading frame 1 immunohistochemistry to detect and localize EBV in paraffin sections of MCC from five patients as well as seven other cutaneous tumors and positive controls for EBV infection.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Positive controls reacted appropriately. However, there was no evidence of latent or lytic EBV in any of the MCC biopsies or other cutaneous tumors.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our findings suggest that EBV is not associated with MCC.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00498.x","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T14:11:10Z","timestamp":1157551870000},"page":"624-628","source":"Crossref","is-referenced-by-count":16,"title":["No evidence of Epstein\u2013Barr virus association with Merkel cell carcinoma"],"prefix":"10.1111","volume":"33","author":[{"given":"Maren","family":"Shaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Groben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L.","family":"Gulley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,6]]},"reference":[{"issue":"3","key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1524-4725.1996.tb00317.x","article-title":"Merkel cell carcinoma","volume":"22","author":"O\u2019Connor WJ","year":"1996","journal-title":"Dermatol Surg"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20167"},{"key":"e_1_2_6_4_2","volume-title":"Pathology of the Skin with Clinical Correlations","author":"McKee P","year":"1999"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114732"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07668-7"},{"issue":"1","key":"e_1_2_6_7_2","first-page":"24","article-title":"Oral Hairy leukoplakia with ultrastructural evidence of Merkel\u2010like cells in human tongue epithelium","volume":"40","author":"Cobb M","year":"1998","journal-title":"Bull Group Int Rech Sci Stomatol Odontol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.14.4510"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.5.833"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60642-3"},{"key":"e_1_2_6_12_2","first-page":"2343","article-title":"Epstein\u2013Barr virus and its replication","volume":"3","author":"Kieff E","year":"1996","journal-title":"Fields Virology"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.53.5.219"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.11.3265"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710600416"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.53.5.255"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199411000-00010"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9619"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910430508"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1312750"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198512193132502"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(97)83541-X"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.53.5.238"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.2.588"},{"issue":"2","key":"e_1_2_6_25_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00129039-200206000-00001","article-title":"Thyroid transcirption factor\u20101: a review","volume":"10","author":"Lau SK","year":"2002","journal-title":"Appl Immunohistochem Molecul Morphol"},{"issue":"2","key":"e_1_2_6_26_2","first-page":"239","article-title":"Detection and characterization of Epstein\u2013Barr virus in clinical specimens","volume":"145","author":"Ambinder RF","year":"1994","journal-title":"Am J Pathol"},{"issue":"2","key":"e_1_2_6_27_2","first-page":"37","article-title":"Epstein\u2013Barr virus DNA loss from tumour cells and the geography of Burkitt\u2019s lymphoma","volume":"7","author":"Sixbey J","year":"2000","journal-title":"Epstein\u2013Barr Virus Rep"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02108-X"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00498.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00498.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T04:03:56Z","timestamp":1696997036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00498.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00498.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00498.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}