{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:23:22Z","timestamp":1770823402274,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T00:00:00Z","timestamp":1156896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> CD99, also known as p30\/32, is a glycoprotein product of the MIC2 gene. It was originally utilized in immunohistochemistry as a unique marker for Ewing sarcoma, other primitive neuroectodermal tumors, and subsequently in other tumors. Its expression in malignant melanoma (MM) has not been well documented, with just two isolated cases of MM recently reported. Recent studies have documented CD99 expression in a significant percentage of atypical fibroxanthomas (AFX), posing potential diagnostic problems in differentiating these two entities. As mistaking MM for AFX based on immunohistochemical staining pattern has significant consequences, we sought to determine the percentage of invasive MM in our archives that have this staining pattern.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Seventy\u2010eight cases of invasive melanoma were retrieved from our files. Each case was stained with mouse anti\u2010human CD99 and evaluated for membranous expression.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Our evaluation revealed that 47 of 78 MM cases (60%) stain positive for CD99.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This study is the first to demonstrate, in a large series, the prevalence of CD99 expression in primary cutaneous melanoma. Additionally, this introduces in the histologic differential diagnosis of CD99 expressing dermal spindle cell lesions.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00524.x","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T19:43:32Z","timestamp":1156967012000},"page":"663-666","source":"Crossref","is-referenced-by-count":27,"title":["Immunoreactivity of CD99 in invasive malignant melanoma"],"prefix":"10.1111","volume":"33","author":[{"given":"Anne E.","family":"Wilkerson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriden A.","family":"Glasgow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M.","family":"Hiatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","DOI":"10.1042\/bj2620369","article-title":"Identification and immunochemical characterization of the human erythrocyte membrane glycoproteins that carry the Xga antigen","volume":"262","author":"Herron R","year":"1989","journal-title":"Biochem J"},{"key":"e_1_2_5_3_2","article-title":"Biochemical and genetic characterization of the HBA71 ewing\u2019s sarcoma cell surface antigen","volume":"51","author":"Fellinger EJ","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","DOI":"10.1042\/bj2470757","article-title":"Immunochemical characterization of the human blood cell membrane glycoprotein recognized by the monoclonal antibody 12e7","volume":"247","author":"Latron F","year":"1987","journal-title":"Biochem J"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","DOI":"10.1002\/1097-0142(19910401)67:7<1886::AID-CNCR2820670712>3.0.CO;2-U","article-title":"MIC2 is a specific marker for ewing\u2019s sarcoma and peripheral primitive neuroectodermal tumors. 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