{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:58:57Z","timestamp":1761843537000},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T00:00:00Z","timestamp":1157500800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The Fli\u20101 transcription factor functions in cellular proliferation and tumorigenesis. Its role in various neoplasms and its presence in lymphocytes suggest a link between Fli\u20101 dysregulation and the pathogenesis of mycosis fungoides (MF). In this study, we further elucidate this possible link.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sections from archived specimens were stained using a polyclonal antibody against Fli\u20101. The percentage of nuclei showing Fli\u20101 expression was recorded. These were compared with reactive dermatoses.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All of the tumor stage lesions showed high levels of nuclear Fli\u20101 expression. Of plaque stage lesions, six of 12 (50%) showed the same intensity, while the remaining six of 12 varied significantly in their Fli\u20101 expression. The few patch stage lesions also showed varied expression.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This study shows diffuse nuclear expression of Fli\u20101 in all tumor stage MF, whereas expression of this transcription factor varied widely in the early, epidermotropic stages. Although the numbers are too small to draw statistical significance, this study demonstrates an association between increased expression of Fli\u20101 and progression to tumor stage MF that merits further investigation. Additionally, the mixed expression of Fli\u20101 in the epidermotropic stages suggests that the role of Fli\u20101 in MF is related to neoplasia and not epidermotropism.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00535.x","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T14:11:10Z","timestamp":1157551870000},"page":"642-645","source":"Crossref","is-referenced-by-count":10,"title":["Fli\u20101 expression in mycosis fungoides*"],"prefix":"10.1111","volume":"33","author":[{"given":"C. Matthew","family":"Quick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce R.","family":"Smoller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M.","family":"Hiatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(03)00115-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200012000-00010"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201628200"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204042"},{"key":"e_1_2_5_6_2","first-page":"2167","article-title":"Analysis of the DNA\u2010binding and transcriptional activation functions of human Fli\u20101 protein","volume":"8","author":"Rao VN","year":"1993","journal-title":"Oncogene"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63685-1"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00011"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032810"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00535.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00535.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T04:04:01Z","timestamp":1696997041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00535.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00535.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00535.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}