{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:55:02Z","timestamp":1774608902002,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T00:00:00Z","timestamp":1157500800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We report a unique case of Kaposi\u2019s sarcoma (KS)\u2010associated herpesvirus (KSHV)\/human herpesvirus (HHV)8\u2010associated lymphoma in a 56\u2010year\u2010old man with a history of acquired immune deficiency syndrome, Castleman\u2019s disease, KS, and idiopathic thrombocytopenic purpura. Three months following the diagnosis of KS affecting a left cervical lymph node and Castleman\u2019s disease with bone marrow involvement, he presented with a subcutaneous, tender lesion on his left arm. A skin biopsy demonstrated a superficial and deep, interstitial\u2010nodular infiltrate of severely atypical lymphoid cells showing plasmacytoid features, numerous mitotic figures, and frequent individual apoptotic tumor cells. The morphologic features were those of plasmablastic lymphoma (PBL). Immunohistochemical study showed that the lymphoma cells strongly expressed CD45, CD30, and KSHV\/HHV8 latency\u2010associated nuclear antigen. KSHV\/HHV8 was also detected in the biopsy sections of the patient\u2019s KS and Castleman\u2019s disease. Epstein\u2013Barr virus <jats:italic>in situ<\/jats:italic> hybridization was diffusely positive. <jats:italic>In situ<\/jats:italic> hybridization demonstrated \u03ba\u2010light chain restriction. Although KSHV\/HHV8 has been individually associated with KS, Castleman\u2019s disease, and PBL, this appears to be the first reported case in which all three entities were present simultaneously in one person, suggesting a critical role of KSHV\/HHV8 as a common denominator in the pathogenesis of these diseases.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00539.x","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T13:59:27Z","timestamp":1157551167000},"page":"46-51","source":"Crossref","is-referenced-by-count":36,"title":["KSHV\/HHV8\u2010associated primary cutaneous plasmablastic lymphoma in a patient with Castleman\u2019s disease and Kaposi\u2019s sarcoma"],"prefix":"10.1111","volume":"33","author":[{"given":"Wenhua","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario E.","family":"Lacouture","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Dickstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyoumars","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Shea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80398-0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505043321802"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V86.4.1276.bloodjournal8641276","article-title":"Kaposi\u2019s sarcoma\u2010associated herpesvirus\u2010like DNA sequences in multicentric Castleman\u2019s disease","volume":"86","author":"Soulier J","year":"1995","journal-title":"Blood"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0487"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.7.2130"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00018-5"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00003"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200405000-00020"},{"key":"e_1_2_5_11_2","volume-title":"Pathology and Genetics: Tumors of Haematopoietic and Lymphoid Tissues. 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