{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:50:29Z","timestamp":1782251429988,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T00:00:00Z","timestamp":1156896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Psoriasis is characterised by hyperproliferation and by aberrant differentiation. Blockage of the normal apoptotic process is one of the factors implicated in the pathogenesis.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To determine the apoptotic features by using TUNEL method and also bcl\u20102 and p53 expressions in psoriatic epidermis.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> Biopsies of 35 patients with psoriasis vulgaris and 14 normal skin were evaluated. Apoptotic cells were detected using the dUTP nick\u2010end labelling assay; bc1\u20102 and p53 expressions were assessed by using immunohistochemical techniques. A semi\u2010quantitative grading system (HSCORE) was used for comparison.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Bcl\u20102 was strongly expressed in basal keratinocytes of normal skin, while no expression was observed in 13 (37.2%) of the psoriatic samples and it was weakly expressed in the spinous cell layer of 22 (62.8%) samples. Moderate p53 expression was observed in the psoriasis group, while it was weak in the control. The percentage of TUNEL positive cells were significantly increased in the psoriasis group (65\u00b12.30) when compared with the control (32.84\u00b17.16).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Apoptotic index besides bc1\u20102 and p53 expressions in psoriasis differ from normal epidermis. Down\u2010regulation of bc1\u20102 is consistent with the dynamics of psoriasis but increased TUNEL positive cells and p53 expression has not been fully elucidated yet.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00564.x","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T16:49:27Z","timestamp":1156956567000},"page":"788-792","source":"Crossref","is-referenced-by-count":20,"title":["Examination of bcl\u20102 and p53 expressions and apoptotic index by TUNEL method in psoriasis"],"prefix":"10.1111","volume":"33","author":[{"given":"Kamer","family":"G\u00fcnd\u00fcz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyker","family":"Demireli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Vatansever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isil","family":"Inanir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(01)00162-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00244.x"},{"key":"e_1_2_5_4_2","first-page":"319","article-title":"Progress in our understanding of the biology of psoriasis","volume":"64","author":"Karasek MA","year":"1999","journal-title":"Cutis"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089160409000124"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.05.008"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.01.003"},{"key":"e_1_2_5_8_2","first-page":"1321","article-title":"Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin","volume":"151","author":"Wrone\u2010Smith T","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01821.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12413590"},{"key":"e_1_2_5_11_2","first-page":"1079","article-title":"Discordant expression of Bcl\u2010x and Bcl\u20102 by keratinocytes in vitro and psoriatic keratinocytes in vivo","volume":"146","author":"Wrone\u2010Smith T","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068289"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018394"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00805.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1999.tb00350.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08552.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750010959"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00564.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00564.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:49:08Z","timestamp":1697053748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00564.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,30]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00564.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00564.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,30]]}}}