{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:09:34Z","timestamp":1791155374562,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T00:00:00Z","timestamp":1156896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Matrix metalloproteinases (MMPs) are associated with Kaposi\u2019s sarcoma (KS) tumorigenesis. To date, only a few MMPs have been studied in KS lesions. Their role in KS regression has not been investigated. The aim of this study was to evaluate the expression of multiple MMPs in developing and pharmacologically regressed KS lesions.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Nine samples of acquired immune deficiency syndrome (AIDS)\u2010related and classic cutaneous KS lesions at various histological stages were studied. Regressing KS lesions from three patients treated with systemic therapy were procured after one and two cycles of chemotherapy. Tissue sections from all specimens were immunostained using monoclonal antibodies to MMP\u20101, MMP\u20102, MMP\u20103, MMP\u20107, MMP\u20109, MMP\u201013, and MMP\u201014.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> KS lesional cells were immunoreactive for all MMPs, except MMP\u201014. Admixed inflammatory cells were immunoreactive for MMP\u20101, MMP\u20102, MMP\u20107, MMP\u20109, and MMP\u201013. The MMP immunoprofile in residual KS lesional cells was unaltered in regressed lesions. Increased extracellular matrix (ECM) and macrophage immunoreactivity for MMPs was identified in regressed specimens.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These data show that developing KS lesional cells express collagenases (MMP\u20101, MMP\u201013), gelatinases (MMP\u20102, MMP\u20109), stromelysin\u20101 (MMP\u20103), and matrilysin (MMP\u20107) but not the membrane\u2010type MMP\u201014. This MMP expression profile is retained by residual KS cells and also expressed by infiltrating macrophages in regressed KS lesions.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00567.x","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T16:49:27Z","timestamp":1156956567000},"page":"793-798","source":"Crossref","is-referenced-by-count":23,"title":["Matrix metalloproteinases in the progression and regression of Kaposi\u2019s sarcoma"],"prefix":"10.1111","volume":"33","author":[{"given":"Liron","family":"Pantanowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Dezube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Hernandez\u2010Barrantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Tahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa K.","family":"Dabbous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.3.178"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","DOI":"10.1007\/s002800051097","article-title":"Matrix metalloproteinases and metastasis","volume":"43","author":"Kleiner DE","year":"1999","journal-title":"Cancer Chemother Pharmacol"},{"key":"e_1_2_6_4_2","article-title":"The role of HIV\u20101 in the pathogenesis of AIDS\u2010related Kaposi\u2019s sarcoma: the importance of an inflammatory and angiogenic milieu","volume":"27","author":"Dezube BJ","year":"2000","journal-title":"Semin Oncol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200409000-00006"},{"key":"e_1_2_6_6_2","article-title":"Inhibition of AIDS\u2010Kaposi\u2019s sarcoma cell induced endothelial cell invasion by TIMP\u20102 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti\u2010angiogenic therapy","volume":"6","author":"Benelli R","year":"1994","journal-title":"Oncol Res"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.10-6-412"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.143.8.3114"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-1281(99)80031-2"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.10.2934"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0303-6987.2004.0132.x"},{"key":"e_1_2_6_12_2","article-title":"Management of AIDS\u2010related Kaposi\u2019s sarcoma: advances in target discovery and treatment","volume":"14","author":"Dezube BJ","year":"2004","journal-title":"AIDS Read"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200109000-00009"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199409000-00004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.1.153"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-004-0020-7"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05561.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199807010-00002"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0302-225"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1309\/LK1V7R99JL41WVKP"},{"issue":"13","key":"e_1_2_6_21_2","article-title":"Use of liposomal anthracyclines in Kaposi\u2019s sarcoma","volume":"31","author":"Krown SE","year":"2004","journal-title":"Semin Oncol"},{"key":"e_1_2_6_22_2","article-title":"Imatinib\u2010induced regression of AIDS\u2010related Kaposi\u2019s sarcoma","volume":"23","author":"Koon HB","year":"2005","journal-title":"J Clin Oncol"},{"key":"e_1_2_6_23_2","article-title":"Inhibition of angiogenesis\u2010driven Kaposi\u2019s sarcoma tumor growth in nude mice by oral N\u2010acetylcysteine","volume":"61","author":"Albini A","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00119080"},{"key":"e_1_2_6_25_2","article-title":"Macrophage and lymphocyte potentiation of syngeneic tumor cell and host fibroblast collagenolytic activity","volume":"48","author":"Dabbous MK","year":"1988","journal-title":"Cancer Res"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00567.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00567.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:49:15Z","timestamp":1697053755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00567.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,30]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00567.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00567.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,30]]}}}