{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:32:16Z","timestamp":1791729136713,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract:\u2002<\/jats:bold>\n                    A 44\u2010year\u2010old man was referred for a right chest nodule of 3 months duration. A \u2018benign\u2019 nodule had been excised from this location 8 years prior. On examination, palpable nodes were noted in the right axilla. Radiographic studies were significant only for right axillary lymphadenopathy. Histologically, a nodular dermal proliferation composed of poorly differentiated epithelioid cells in nests and focally forming ducts with pseudopapillary architecture comprised the primary tumor. Features of a clear cell hidradenoma were noted focally. Immunohistochemical (IHC) analysis revealed reactivity for HMW cytokeratins, CK5 and CK7, p53, p63, CEA (focal), androgen receptor, EGFR, estrogen receptor (ER), MUC5AC, and strong\/diffuse membranous staining for Her\u20102\/\n                    <jats:italic>neu<\/jats:italic>\n                    . Negative stains included villin, TTF\u20101, CDX2, S\u2010100 protein, vimentin, gross cystic disease fluid protein 15 (GCDFP\u201015), mammoglobulin, and MUC2. A wide local excision and axillary node dissection was performed. Metastatic tumor involved nine of 28 nodes. Interphase fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH) demonstrated chromosomal amplification of the\n                    <jats:italic>Her\u20102\/neu<\/jats:italic>\n                    locus within the tumor and a nodal metastasis. The patient has completed adjuvant and radiotherapy, including trastuzumab, and is asymptomatic. We believe this to be the first demonstration of\n                    <jats:italic>Her\u20102\/neu<\/jats:italic>\n                    amplification in a malignant skin adnexal tumor. In analogy to breast carcinoma, these findings suggest the applicability of trastuzumab for patients with metastatic adnexal carcinomas demonstrating\n                    <jats:italic>Her\u20102\/neu<\/jats:italic>\n                    amplification.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00570.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T11:42:16Z","timestamp":1158061336000},"page":"49-54","source":"Crossref","is-referenced-by-count":66,"title":["Metastatic hidradenocarcinoma with demonstration of\n                    <i>Her\u20102\/neu<\/i>\n                    gene amplification by fluorescence\n                    <i>in situ<\/i>\n                    hybridization: potential treatment implications"],"prefix":"10.1111","volume":"34","author":[{"given":"Jason W.","family":"Nash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry L.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merrill","family":"Kies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merrick I","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Sneige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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