{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:46:42Z","timestamp":1778716002155,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Lifetime risk for squamous cell carcinoma (SCC) of the skin is 1:30. Risk in organ\u2010transplant recipients (OTR) is increased over 60\u2010fold through long\u2010term drug\u2010induced immunosuppression. MAGE family\u2010derived peptides are cancer\/testis antigens recognized by specific CD8<jats:sup>+<\/jats:sup> T cells and employed for immunotherapy. We were interested in the frequency and distribution of MAGE\u2010A4 in epithelial skin tumors of OTR and immunocompetent patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> mAb 57B predominantly recognizing MAGE\u2010A4 was used to stain 119 formalin\u2010fixed, paraffin\u2010embedded epithelial skin tumors (actinic keratosis, bowenoid actinic keratosis, Bowen\u2019s disease, and SCC; n\u2003=\u200317, 25, 61, 16, respectively) in immunocompetent patients (n\u2003=\u200384) and OTR (n\u2003=\u200335).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All four epithelial skin tumors showed comparable immunoreactivity ranging from (25\u201371%, p\u2003=\u20030.361). Scattered immunoexpression pattern was more frequent in OTR (p\u2003=\u20030.025). SCC showed polarized immunoreactivity basally (p\u2003=\u20030.002).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> MAGE\u2010A4 was expressed in a large part of epithelial skin tumors with predominantly scattered immunoexpression pattern in OTR. The difference in immunoexpression pattern for immune status was limited, suggesting important non\u2010immunosuppressor\u2010mediated mechanisms for increased skin carcinogenesis in OTR. mAb 57B may be a helpful tool for immunohistochemistry and micrographic surgery using formalin\u2010fixed paraffin\u2010embedded tissue.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00576.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T15:42:16Z","timestamp":1158075736000},"page":"1-6","source":"Crossref","is-referenced-by-count":16,"title":["Cancer\/testis antigen MAGE\u2010A4 expression pattern differs in epithelial skin tumors of organ\u2010transplant recipients and immunocompetent patients"],"prefix":"10.1111","volume":"34","author":[{"given":"Beda","family":"Muehleisen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Schaerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Dummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Burg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther F. 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