{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:06:56Z","timestamp":1793477216026,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:00:00Z","timestamp":1163635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> CD23 expression in normal B lymphocytes is limited to autoreactive B cells, na\u00efve B cells and mature B cells manifesting an activated phenotype. As a marker of hematologic dyscrasia\/malignancy, expression of CD23 is associated with small lymphocytic lymphoma\/chronic lymphocytic leukemia. An absence of CD23 expression within small lymphocytes is typically seen in marginal zone lymphoma and mantle cell lymphoma. Positive CD23 expression amidst neoplastic cells in primary cutaneous B\u2010cell lymphoma is not a reported phenomenon.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This paper reports nine patients with cutaneous B\u2010cell lymphoma manifesting CD23 expression.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In seven of the nine cases CD23 expression was observed in the setting of recurrent disease, being present in both large and small lymphocytes. CD23 expression paralleled staining for CD40 in all but one case.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> A potential mechanism of CD23 upregulation may involve the anti\u2010apoptotic nuclear kappa beta CD40\u2013CD40 ligand pathway. Neoplastic B cells manifesting CD23 expression could have a survival advantage, predisposing to recurrent disease and or oncogenic events permissive to disease progression.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00653.x","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T13:53:32Z","timestamp":1163685212000},"page":"461-466","source":"Crossref","is-referenced-by-count":6,"title":["The expression of CD23 and CD40 in primary cutaneous B\u2010cell lymphomas"],"prefix":"10.1111","volume":"34","author":[{"given":"Cynthia","family":"Magro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00017-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1309\/VWTK-XYT5-D0DK-06HQ"},{"key":"e_1_2_6_4_2","article-title":"The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease","volume":"94","author":"DiRaimondo F","year":"1721","journal-title":"Cancer"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.10045"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1309\/XV4AG7EMWQU7ER67"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1478"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.800"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.50.269"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.2.173"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236924"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/8.6.815"},{"key":"e_1_2_6_13_2","first-page":"157","volume":"14","author":"Chung JB","year":"2002","journal-title":"CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals"},{"key":"e_1_2_6_14_2","first-page":"722","article-title":"Immunohistochemical expression of CD23 and CD40 may identify prognostically favorable subgroups of diffuse large B\u2010cell lymphoma: a Nordic Lymphoma Group Study","volume":"9","author":"Linderoth J","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000095895.19756.77"},{"key":"e_1_2_6_16_2","first-page":"106","article-title":"Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis","volume":"2005","author":"Ruiz\u2010Ballesteros E","year":"1831","journal-title":"Blood"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.762"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00653.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00653.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:06:36Z","timestamp":1696964796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00653.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,18]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00653.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00653.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,18]]}}}