{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:14:07Z","timestamp":1792030447011,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T00:00:00Z","timestamp":1181260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Our study evaluated the expression of vascular endothelial growth factor (VEGF), CD31 and D2\u201040 in involved and uninvolved skin of 18 patients with rosacea.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Immunostaining of facial skin specimens with VEGF, CD31 and D2\u201040 was compared between the lesional and the non\u2010lesional skin of patients with erythemotelangiectatic and papulopustular rosacea.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Significantly increased dermal expression of VEGF in lesional vs. non\u2010lesional skin (88.9% and 55.6%) was observed. Dermal expression of CD31 and D2\u201040 was also increased in lesional vs. non\u2010lesional skin. There was no statistically significant difference in cutaneous expression of VEGF, CD31 and D2\u201040 between patients with papulopustular and erythemotelangiectatic rosacea, and no correlation was found between disease duration and immunoreactivity of VEGF, CD31or D2\u201040.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our study showed marked immunostaining of lesional skin with VEGF, CD31 and D2\u201040 compared with non\u2010lesional skin. Increased immunoreactivity of D2\u201040 in lesional skin is interesting, given that none of the patients had facial edema. There are no published data regarding the role of lymphangiogenesis in patients with non\u2010phymatous rosacea; thus, our study represents a new understanding of its pathogenesis. Lack of correlation between D2\u201040 expression and disease duration suggests that lymphatics are involved early in the pathogenesis of rosacea and do not constitute a late event.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00695.x","type":"journal-article","created":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T11:44:30Z","timestamp":1181303070000},"page":"748-753","source":"Crossref","is-referenced-by-count":101,"title":["Lymphangiogenesis and angiogenesis in non\u2010phymatous rosacea"],"prefix":"10.1111","volume":"34","author":[{"given":"Amal H. A.","family":"Gomaa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Yaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa M. K.","family":"Eyada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jag","family":"Bhawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,18]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Textbook of dermatology","author":"Greaves MW","year":"1998"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59715-2"},{"key":"e_1_2_6_4_2","unstructured":"Lancet 1981 1 Rosacea in hot water"},{"key":"e_1_2_6_5_2","volume-title":"Acne and related disorders","author":"Marks R","year":"1989"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","DOI":"10.1001\/archderm.1995.01690210105020","article-title":"Persistent facial swelling in a patient with rosacea. 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