{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:35:09Z","timestamp":1783485309473,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T00:00:00Z","timestamp":1181260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Premature desquamation of the inner root sheath (IRS) is described as a defining histologic feature of follicular degeneration syndrome\/central centrifugal cicatricial alopecia (CCCA). However, IRS abnormalities have been noted in other types of alopecia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design:\u2002<\/jats:bold>\n                    We evaluated the IRS in terminal hair follicles with transverse sections stained with hematoxylin\u2010eosin and Ziehl\u2010Neelsen stains in 22 non\u2010scarring (7 areata and 15 androgenetic) and 21 scarring (13 CCCA, 2 lichen planopilaris, 2 lupus erythematosus, 1 folliculitis decalvans and 3 end stage) alopecia cases. In addition, we evaluated 15 normal controls with longitudinal sections to establish the level of IRS desquamation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    The IRS was present in 99.5 \u00b1 0.01% (mean \u00b1 standard error) of normal follicles at the level of the arrector pili muscle\/sebaceous gland\/sweat gland coil (L2) and variably present at higher levels. The IRS was present at L2 in 97.9 \u00b1 1.5% of alopecia areata, 87.4 \u00b1 5.3% of androgenetic alopecia, 59.3 \u00b1 7.0% of CCCA and 49.4 \u00b1 11.3% of other scarring alopecia follicles.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Premature desquamation of the IRS was identified in CCCA; however, it was also noted in other scarring alopecia cases. IRS premature desquamation is a non\u2010specific histologic feature in scarring alopecia and cannot be used alone as a defining feature of CCCA.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00696.x","type":"journal-article","created":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T07:45:45Z","timestamp":1181288745000},"page":"762-768","source":"Crossref","is-referenced-by-count":27,"title":["Investigation of the hair follicle inner root sheath in scarring and non\u2010scarring alopecia"],"prefix":"10.1111","volume":"34","author":[{"given":"Marcelo G","family":"Horenstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680110078010"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70403-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.4.479"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650400031009"},{"key":"e_1_2_6_6_2","unstructured":"ProphetEB MillsB ArringtonJB SobinLH.AFIP laboratory methods in histotechnology. 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Basal cell carcinoma associated with a vellus hair cyst","volume":"129","author":"Law AM","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1968.01610150020003"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00231.x"},{"issue":"48","key":"e_1_2_6_10_2","first-page":"103","article-title":"Summary of North American Hair Research Society (NAHRS)\u2010sponsored workshop on cicatricial alopecia, Duke University Medical Center, February 10 and 11","volume":"2003","author":"Olsen EA","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.280701.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/archderm.1994.01690060093012","article-title":"Follicular degeneration syndrome in men","volume":"130","author":"Sperling LC","year":"1994","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.07.069"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401500305"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(71)80109-0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1268"},{"key":"e_1_2_6_17_2","first-page":"156","article-title":"Asebia\u20102J (Scd1(ab2J)): a new allele and a model for scarring alopecia","volume":"2000","author":"Sundberg JP","year":"2067","journal-title":"Am J Pathol"},{"key":"e_1_2_6_18_2","first-page":"1","article-title":"Characterization of the lipid composition at the proximal root regions of human hair","volume":"56","author":"Masukawa Y","year":"2005","journal-title":"J Cosmet Sci"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00696.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00696.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T11:07:04Z","timestamp":1697022424000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00696.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,18]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00696.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00696.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1098035.554007","asserted-by":"object"}]},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,18]]}}}