{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:16:32Z","timestamp":1772640992098,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T00:00:00Z","timestamp":1180137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Perineurioma is a rare benign soft\u2010tissue tumor composed of cells showing differentiation toward the perineurial cells of the nerve sheath. Although mutations in the neurofibromatosis 2 (NF2) gene have been documented in this tumor, there is no known association between perineuriomas and type 1 or 2 NF.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This is the first report of a case of soft\u2010tissue perineurioma occurring in a patient with NF1.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Histopathologic examination revealed a 2.0\u2010cm well\u2010circumscribed, spindle\u2010cell neoplasm with slender, elongated, bipolar, wavy cytoplasmic processes and wavy, elongated nuclei in a hyalinized stroma with focal myxoid areas. The architecture was composed predominantly of short fascicles with areas exhibiting a storiform pattern. Immunohistochemistry showed positive labeling for epithelial membrane antigen (EMA) but no staining for S\u2010100 and smooth muscle actin (SMA).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This case illustrates that perineurioma can occur in association with NF1. Perineuriomas can be confused with other spindle\u2010cell neoplasms, and relevant features and immunohistochemistry of these lesions are outlined. The patient has not had a recurrence with limited follow\u2010up.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00702.x","type":"journal-article","created":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T11:51:42Z","timestamp":1180180302000},"page":"726-730","source":"Crossref","is-referenced-by-count":24,"title":["Soft\u2010tissue perineurioma in a 20\u2010year\u2010old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature"],"prefix":"10.1111","volume":"34","author":[{"given":"Gregory G.","family":"Ausmus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa P.","family":"Piliang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma F.","family":"Bergfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Goldblum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,10]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"41","article-title":"Ultrastructural identification of a benign perineurial cell tumor","volume":"1978","author":"Lazarus SS","year":"1823","journal-title":"Cancer"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199702000-00005"},{"key":"e_1_2_7_4_2","first-page":"1111","volume-title":"Enzinger and Weiss\u2019s soft tissue tumors","author":"Weiss SW","year":"2001"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550010065042"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.3.608"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/103.6.696"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/00313020410001721663"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200106000-00005"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000155166.86409.d2"},{"key":"e_1_2_7_12_2","first-page":"21","article-title":"Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults","volume":"1997","author":"Fetsch JF","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199907000-00015"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.1.2"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-1-39"},{"key":"e_1_2_7_16_2","first-page":"20","article-title":"Precise localization of NF1 to 17q11.2 by balanced translocation","volume":"44","author":"Ledbetter DH","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00008"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.00108.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199904000-00009"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00702.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00702.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:42:25Z","timestamp":1696966945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00702.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,10]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00702.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00702.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,10]]}}}