{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:17:08Z","timestamp":1789885028431,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T00:00:00Z","timestamp":1181260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Pseudoxanthoma elasticum (PXE) is an inherited disorder leading to characteristic calcified elastic fibers in skin, eyes and vasculature. PXE\u2010like fibers have not been described in inflammatory skin disease in the absence of other signs of PXE.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The histopathology of inflamed skin from 13 patients that contained PXE\u2010like fibers but lacked clinical evidence of PXE were studied. Six of these and six comparison specimens from known patients with PXE were subjected to polymerase chain reaction amplification and sequencing of exons 24 and 28 of the PXE\u2010associated gene <jats:italic>ABCC6<\/jats:italic>. This genetic analysis employed a novel assay utilizing paraffin\u2010embedded tissue.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Incidental PXE\u2010like fibers were found in patients without clinical suspicion of PXE in lesional tissue showing lipodermatosclerosis, granuloma annulare, lichen sclerosus, morphea profunda, erythema nodosum, septal panniculitis, basal cell carcinoma and fibrosing dermatitis. Two patients with PXE\u2010like fibers but without clinical findings of PXE were heterozygous for a PXE\u2010associated <jats:italic>ABCC6<\/jats:italic> sequence alteration.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This pilot study shows elastic fibers similar to those of PXE in the lesional skin of patients with a variety of inflammatory skin diseases in the absence of clinical evidence of PXE; and some of these patients harbor changes in <jats:italic>ABCC6<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00705.x","type":"journal-article","created":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T11:48:47Z","timestamp":1181303327000},"page":"777-781","source":"Crossref","is-referenced-by-count":28,"title":["Pseudoxanthoma elasticum\u2010like fibers in the inflamed skin of patients without pseudoxanthoma elasticum"],"prefix":"10.1111","volume":"34","author":[{"given":"Anneli R.","family":"Bowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"G\u00f6tting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"LeBoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.","family":"McCalmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,18]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"122","article-title":"Pseudoxanthoma elasticum \u2013 a connective tissue disease or a metabolic disorder at the genome\/environment interface?","author":"Uitto J","year":"2004","journal-title":"J Invest Dermatol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20206"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9284"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690527"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.100401.x"},{"key":"e_1_2_5_7_2","first-page":"126","article-title":"Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitro","volume":"2006","author":"Le Saux O","journal-title":"J Invest Dermatol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700004"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22312.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20632"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198708063170604"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.112401"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199908000-00009"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199608000-00011"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/323704"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00705.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00705.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:07:23Z","timestamp":1697036843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00705.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,18]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00705.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00705.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,18]]}}}