{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:06:17Z","timestamp":1766268377817},"reference-count":44,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T00:00:00Z","timestamp":1181088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Post\u2010transplant lymphoproliferative disease (PTLD) is a recognized complication of the immunosuppressive regimens associated with solid organ transplantation. The vast majority of these lesions represent monomorphic B\u2010cell lymphoproliferative disease. Rarely, however, T\u2010cell malignancies may emerge, the commonest being anaplastic large\u2010cell lymphoma (ALCL).<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> We describe two patients who developed a post\u2010transplant ALCL several years after transplantation. Comprehensive phenotypic and molecular studies were conducted. The technique of capillary gel electrophoresis was employed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> One patient died of unrelated causes, while the other patient did achieve clinical remission. The neoplastic cell populace was composed of CD4\u2010positive cytotoxic T cells exhibiting CD30 positivity. There were very few B cells. Striking and prominent clonally restricted infiltrates were identified whereby there was both a heavy chain and T\u2010cell beta gene rearrangement. There was no evidence of lytic Epstein\u2010Barr virus (EBV) infection.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> T\u2010cell\u2010associated PTLD does not appear to be directly attributable to EBV infection. Iatrogenic immune dysregulation may result in excessive T\u2010cell proliferation to various antigenic stimuli, hence resembling other drug\u2010associated cell lymphoproliferative conditions such as angioimmunoblastic lymphadenopathy. The dual rearrangement may have some implications regarding the cell of origin.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00712.x","type":"journal-article","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T14:30:15Z","timestamp":1181140215000},"page":"1-8","source":"Crossref","is-referenced-by-count":23,"title":["Post\u2010transplant EBV\u2010negative anaplastic large\u2010cell lymphoma with dual rearrangement: a propos of two cases and review of the literature"],"prefix":"10.1111","volume":"34","author":[{"given":"Cynthia M.","family":"Magro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Weinerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Luigi","family":"Porcu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl D.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.2.552.552"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987445"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2001.003002060.x"},{"key":"e_1_2_5_5_2","first-page":"35","article-title":"Posttransplant lymphoproliferative disease: treatment and outcome in renal transplant recipients","volume":"2003","author":"Soler MJ","year":"1709","journal-title":"Transplant Proc"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1654(199910\/12)9:4<263::AID-RMV256>3.0.CO;2-D"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1140"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-946.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200010)62:2<239::AID-JMV16>3.0.CO;2-Z"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02748.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2003.00098.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880218"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00421-6"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03925.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703953"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20191"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/6.11.896"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199205000-00032"},{"key":"e_1_2_5_19_2","first-page":"327","article-title":"Brief report: successive occurrence of T\u2010cell and B\u2010cell lymphomas after renal transplantation in a patient with multiple cutaneous squamous\u2010cell carcinomas","volume":"1992","author":"Euvrard S","year":"1924","journal-title":"N Engl J Med"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199308000-00010"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70220-N"},{"key":"e_1_2_5_22_2","first-page":"512","article-title":"Cutaneous T\u2010cell post\u2010transplant lymphoproliferative disorder clinically masquerading as cellulitis and presenting with subcutaneous lesions. 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