{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:20:21Z","timestamp":1761708021963},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T00:00:00Z","timestamp":1169769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> In the absence of mites, the histologic diagnosis of human scabies can be difficult. Scabies can mimic a variety of inflammatory and lymphoproliferative disorders. It is under\u2010recognized that scabies can also mimic Langerhans cell histiocytosis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sixteen examples of scabies were reviewed histologically and immunohistochemically (CD1a, CD3, CD20, CD30 and S100).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Immunohistochemical labeling showed florid CD1a and S100 positivity in most cases, indicative of Langerhans cell hyperplasia. Scattered CD30+ lymphocytes were also typically present, within a dense infiltrate, primarily composed of T lymphocytes and eosinophils.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Because of the prominent CD1a+\/S100+ component, scabies can mimic Langerhans cell histiocytosis. This finding should be considered in conjunction with scattered CD30+ cells and clinical features to avoid misdiagnosis.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00723.x","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T16:15:58Z","timestamp":1169828158000},"page":"716-720","source":"Crossref","is-referenced-by-count":44,"title":["Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis"],"prefix":"10.1111","volume":"34","author":[{"given":"Pradip","family":"Bhattacharjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Earl J.","family":"Glusac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","DOI":"10.1001\/archderm.1977.01640030066010","article-title":"Pathologic findings in human scabies","volume":"113","author":"Fernandez N","year":"1977","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1981.tb00844.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198202000-00003"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290608.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200004000-00019"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb00573.x"},{"key":"e_1_2_5_8_2","article-title":"Histology simulating reticulosis in persistent nodular scabies","volume":"90","author":"Thomson J","year":"1974","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_9_2","article-title":"Scabies masquerading as Letterer\u2010Siwe\u2019s disease","volume":"115","author":"Aterman K","year":"1976","journal-title":"CMAJ"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00098.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01105.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10113"},{"key":"e_1_2_5_13_2","article-title":"Sarcoptes scabiei infestation misdiagnosed and treated as Langerhans cell histiocytosis","volume":"12","author":"Burch JM","year":"2004","journal-title":"Pediatr Dermatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1975.03260010055023","article-title":"Scabies masquerading as dermatitis herpetiformis","volume":"233","author":"Ackerman AB","year":"1975","journal-title":"JAMA"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90069-9"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00115.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80272-1"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02608-8"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7226.35"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02472.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00723.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00723.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:42:12Z","timestamp":1696966932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00723.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,10]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00723.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00723.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,10]]}}}