{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:39:24Z","timestamp":1772786364567,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T00:00:00Z","timestamp":1169769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Alopecia is one of the clinical manifestations of secondary syphilis. It is uncommon for hair loss to be the sole or predominant manifestation, as hair loss is the chief clinical and histologic differential diagnosis of alopecia areata. The main difference between these two entities is the detection of <jats:italic>Treponema pallidum<\/jats:italic> in syphilis. We present the case of a 24\u2010year\u2010old Hispanic man, human immunodeficiency virus seropositive in treatment, with tiny patches of non\u2010cicatricial alopecia in the parieto\u2010occipital regions of his scalp. The patient denied previous history of genital or other skin lesions. A biopsy from an alopecic patch was performed which showed an inflammatory non\u2010scarring alopecia with a discrete lymphocytic type inflammatory infiltrate localized in the peribulbar region. There was lymphocyte exocytosis into the matrix, associated with vacuolar degeneration, and scattered apoptotic cells were observed. Plasma cells were scattered. Immunohistochemical studies showed the presence of <jats:italic>T. pallidum<\/jats:italic> limited to the peribulbar region and penetrating into the follicle matrix. To the authors\u2019 knowledge, this is the first time that spirochetes have been shown in the hair follicle in alopecia syphilitica, suggesting that the spirochetes may be pathogenetic and responsible for the alopecia.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2006.00726.x","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T16:15:58Z","timestamp":1169828158000},"page":"37-40","source":"Crossref","is-referenced-by-count":40,"title":["Alopecia syphilitica with detection of <i>Treponema pallidum<\/i> in the hair follicle"],"prefix":"10.1111","volume":"34","author":[{"given":"Syong Hyun","family":"Nam\u2010Cha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Guhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Fern\u00e1ndez\u2010Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","DOI":"10.1097\/00007611-194010000-00032","volume-title":"Diagnosis and treatment of diseases of the hair","author":"McCarthy L","year":"1940"},{"key":"e_1_2_5_3_2","article-title":"Alopecia specifica in secondary syphilis. Molecular detection of Treponema pallidum in lesional skin","volume":"6","author":"Schl\u00fcpen EM","year":"1996","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_4_2","article-title":"Alopecia syphilitica, a simulator of alopecia areata: histopathology and differential diagnosis","volume":"10","author":"Lee JY","year":"1991","journal-title":"J Cutan Pathol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91543-5"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199504000-00008"},{"key":"e_1_2_5_7_2","article-title":"Histologic patterns of secondary syphilis","volume":"107","author":"Jeerepact P","year":"1973","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_8_2","article-title":"Secondary syphilis. A clinicopathological study","volume":"10","author":"Jordaan HF","year":"1988","journal-title":"Am J Dermatopathol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00131-0"},{"key":"e_1_2_5_10_2","article-title":"Fluorescent antibody techniques in early syphilis; as applied to the demonstration of T. pallidumin lesions in the rabbit and in the human","volume":"77","author":"Yobs AR","year":"1964","journal-title":"Arch Pathol"},{"key":"e_1_2_5_11_2","article-title":"Immunofluorescent staining of Treponema pallidum and Treponema pertenue in tissues fixed by formalin and embedded in paraffin wax","volume":"53","author":"Al\u2010Samarrai HT","year":"1977","journal-title":"Br J Vener Dis"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/18.5.315"},{"key":"e_1_2_5_13_2","article-title":"Immunoperoxidase localization of Treponema pallidum","volume":"103","author":"Beckett JH","year":"1979","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1991.32.4.335"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00236.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2006.00726.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2006.00726.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T10:32:03Z","timestamp":1695810723000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2006.00726.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,6]]},"references-count":14,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1600-0560.2006.00726.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2006.00726.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,6]]}}}