{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:59:14Z","timestamp":1758265154574},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T00:00:00Z","timestamp":1169769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Tuberculids are rarely associated with male genital tract tuberculosis (TB). Tuberculous epididymo\u2010orchitis (TBEO) has been associated rarely with papulonecrotic tuberculid (PNT) but not with erythema induratum (EI) or the simultaneous occurrence of different tuberculids.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A retrospective assessment of tuberculids that occurred with underlying TBEO was carried out.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Five patients, four with one and one with two skin biopsies, with clinical diagnoses of PNT (two), EI (one), impetigo (two) and calf ulcer (one), formed the study cohort. Histopathological evaluation confirmed PNT and EI in four and two skin biopsies, respectively. Two patients who returned for follow\u2010up were commenced on anti\u2010tuberculous therapy. All patients sought medical attention 3\u201334 months later for tender right\u2010sided (two) and left\u2010sided (three) testicular masses. Orchidectomy was undertaken following a poor clinical response to empirical treatment with trimethoprim sulfamethoxazole. Pathological examination of the testis and epididymis confirmed TBEO. The patients were initiated on anti\u2010tuberculous therapy. There was dramatic healing of the skin lesions.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Tuberculids are a sentinel cutaneous manifestation of visceral TB and a valuable external audit of treatment compliance and response. Heightened recognition of and more rigorous genitourinary tract investigation are necessary to identify occult or asymptomatic TBEO as the underlying cause of tuberculids.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00716.x","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T16:15:58Z","timestamp":1169828158000},"page":"830-836","source":"Crossref","is-referenced-by-count":10,"title":["Tuberculids as sentinel lesions of tuberculous epididymo\u2010orchitis"],"prefix":"10.1111","volume":"34","author":[{"given":"Pratistadevi K.","family":"Ramdial","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Calonje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive","family":"Sydney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumeshini","family":"Subrayen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phumlani S.","family":"Meyiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamila","family":"Aboobaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,26]]},"reference":[{"key":"e_1_2_7_2_2","article-title":"Cutaneous tuberculosis: a twenty\u2010year prospective study","volume":"3","author":"Kumar B","year":"1999","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_7_3_2","volume-title":"Tuberculosis & nontuberculous mycobacterial infections","author":"McAleer SJ","year":"2006"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb01019.x"},{"key":"e_1_2_7_5_2","volume-title":"Textbook of dermatology","author":"Gawkrodger DJ","year":"1998"},{"key":"e_1_2_7_6_2","article-title":"Cutaneous tuberculosis in Hong Kong: an update","volume":"12","author":"Ho CK","year":"2006","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00053.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1990.tb02012.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199410000-00002"},{"key":"e_1_2_7_10_2","article-title":"The papulonecrotic tuberculide. 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