{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:02:07Z","timestamp":1781553727405,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T00:00:00Z","timestamp":1191974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Pyoderma gangrenosum (PG) is a non\u2010infectious, autoimmune, chronic ulcer of the skin, often co\u2010existing with inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) have been implicated as mediators of tissue destruction in chronic cutaneous and intestinal wounds.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty\u2010four skin biopsies with clinically and histologically confirmed PG and acute wounds were immunostained for MMP\u20101, \u20107, \u20108, \u20109, \u201010 and \u201026; tissue inhibitors of matrix metalloproteinase (TIMP)\u20101 and \u20103 and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> MMP\u20101 was generally expressed by keratinocytes distal from the wound edge, whereas MMP\u201010 was detected abundantly in the epithelium. MMP\u201026 was positive in 42% at the migratory front. Abundant stromal expression was evident for MMP\u20101, \u20109 and \u201010, TIMP\u20101 and \u20103 and TNF\u2010\u03b1. In acute wounds, stromal MMP\u20101, \u20109 and \u201010 and TNF\u2010\u03b1 were sparse.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Unlike in normally healing cutaneous wounds, MMP\u20101 and \u201026 were detected bordering the wound in only a minority of PGs and their lack may thus retard epithelial repair. Particularly, MMP\u20109 and \u201010 and TNF\u2010\u03b1 would be suitable therapeutic targets as they may contribute to the degradation of provisional matrices needed for migration in healing wounds. The presence of MMP\u20101, \u20109, \u201010 and \u201026 in both PG and IBD ulcers may suggest a similar pathogenesis for cutaneous and mucosal inflammation.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00744.x","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T02:16:26Z","timestamp":1192068986000},"page":"889-898","source":"Crossref","is-referenced-by-count":40,"title":["Expression of MMP\u20109, MMP\u201010 and TNF\u2010\u03b1 and lack of epithelial MMP\u20101 and MMP\u201026 characterize pyoderma 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