{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:45:01Z","timestamp":1761155101480},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,15]],"date-time":"2007-08-15T00:00:00Z","timestamp":1187136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>Diffuse malignant peritoneal mesothelioma (DMPM) is a relatively rare neoplasm. Risk factors associated with its development include asbestos exposure, chronic irritation or inflammation of the peritoneum, abdominal radiotherapy, familial Mediterranean fever and simian virus 40. A familial segregation of this neoplasia has been reported in small villages of the Cappadocian region of Turkey, and it has been postulated that hereditary factors may predispose to mesothelioma, even with exposure to small amounts of asbestos. We report a case of DMPM, which apparently occurred in the absence of predisposing factors in a patient with a clinical history characterized by recurrent pre\u2010sacral acne inversa of long duration. The association of this chronic inflammatory disease with DMPM has never been reported. The genetic locus for acne inversa has recently been identified within the 1p21.1\u20131q25.3 chromosomal region. Interestingly, frequent losses in chromosomal region 1p.21\u201322 have been found in mesothelioma as well. It is thus tempting to speculate that genetic mutations involving chromosome 1p.21\u201322 may account for the development of both diseases.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00766.x","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T01:06:00Z","timestamp":1187312760000},"page":"70-73","source":"Crossref","is-referenced-by-count":10,"title":["Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case 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