{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:55:56Z","timestamp":1775267756414,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>While some unequivocally benign infiltrates are easy to distinguish from cutaneous T\u2010cell lymphoma (CTCL), drug\u2010associated lymphomatoid hypersensitivity reaction and cutaneous lesions of collagen vascular disease can show cytologic atypia, clonality and an immunophenotypic profile that closely simulates CTCL and cause diagnostics difficulties. Similar immunophenotypic and molecular abnormalities to those of malignant lymphoma can also be observed in pityriasis lichenoides chronica (PLC), large plaque parapsoriasis (LPP), pigmented purpuric dermatosis (PPD) and atypical lymphocytic lobular panniculitis leading one to consider these entities as forms of cutaneous lymphoid dyscrasia. The purpose of our study was to evaluate the distinction of these various subcategories of cutaneous T\u2010cell infiltrates by assessment of T\u2010cell receptor (TCR)\u2010\u03b2 gene rearrangement. Formalin\u2010fixed paraffin\u2010embedded skin biopsies from 80 patients containing a T\u2010cell dominant lymphocytic infiltrate were analyzed for TCR\u2010\u03b2 gene rearrangement. Our findings indicate that monoclonality is a reliable characteristic of CTCL with polyclonality being very infrequent. However, some cases of drug associated lymphomatoid hypersensitivity, collagen vascular disease and the various cutaneous lymphoid dyscrasias (i.e. PLC, PPD and atypical lymphocytic lobular panniculitis) could manifest restricted molecular profiles in the context of an oligoclonal process or frank monoclonality.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00813.x","type":"journal-article","created":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T07:10:13Z","timestamp":1193901013000},"page":"358-365","source":"Crossref","is-referenced-by-count":40,"title":["Assessment of TCR\u2010\u03b2 clonality in a diverse group of cutaneous T\u2010Cell infiltrates"],"prefix":"10.1111","volume":"35","author":[{"given":"Jose Antonio","family":"Plaza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia M.","family":"Magro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.10.3460"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.21.8536"},{"key":"e_1_2_6_4_2","first-page":"821","article-title":"The rapid detection of clonal T\u2010cell proliferations in patients with lymphoid disorders","volume":"138","author":"McCarthy KP","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12389114"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028005235.x"},{"key":"e_1_2_6_7_2","first-page":"417","article-title":"Clonal T\u2010cell populations in pityriasis lichenoides et varioliformis acuta (Mucha\u2010Habermann disease)","volume":"126","author":"Weiss LM","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.125381"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.0165.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199704000-00003"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90216-2"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90266-6"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60456-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_6_16_2","first-page":"659","article-title":"Molecular immunoglobulin\/T\u2010 cell receptor clonality analysis in cutaneous lymphoproliferations. Experience with the BIOMED\u20102 standardized polymerase chain reaction protocol","volume":"88","author":"Sandberg Y","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60630-7"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028008412.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/319420a0"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027005228.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1133"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200206000-00001"},{"key":"e_1_2_6_23_2","first-page":"169","article-title":"Detection of clonal T\u2010cell receptor gamma gene rearrangements using fluorescent\u2010based PCR and automated high\u2010resolution capillary electrophoresis","volume":"6","author":"Luo V","year":"2001","journal-title":"Mol Diagn"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2007.00813.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2007.00813.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:12:21Z","timestamp":1697422341000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2007.00813.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1600-0560.2007.00813.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2007.00813.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,10]]}}}