{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:46:38Z","timestamp":1789472798238,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T00:00:00Z","timestamp":1194912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p> <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/CUP_842_fu1.gif\" xlink:title=\"inline image\"\/> <\/jats:p><jats:p>Perivascular epithelioid cell (PEC) tumors, also called \u2018PEComas,\u2019 are distinct tumors showing PEC differentiation with characteristic histologic and immunophenotypic features. PEComas are rare tumors documented in the literature presenting in numerous anatomic sites including the thorax, abdomen, pelvis, soft tissue and skin. Criteria for malignancy does not exist for the subset of PEComas that pursue an aggressive clinical course. Herein, we present an unusual case of a malignant PEC tumor presenting as a scalp nodule in a patient with a prior diagnosis of \u2018melanoma\u2019 based upon the immunophenotypic profile of an excised enlarged cervical lymph node. The purpose of this case presentation is to further describe the rare clinical manifestations of a subcutaneous PEC tumor, emphasize the malignant potential of this entity, and review the literature focusing upon clinicopathologic features of cutaneous\/subcutaneous PEComas.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00842.x","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T01:25:04Z","timestamp":1195176304000},"page":"499-503","source":"Crossref","is-referenced-by-count":37,"title":["Malignant perivascular epithelioid cell tumor (\u2018PEComa\u2019): a case report and literature review of cutaneous\/subcutaneous presentations"],"prefix":"10.1111","volume":"35","author":[{"given":"Kenneth B.","family":"Calder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Schlauder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,8]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02105.x"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199203000-00013"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199102000-00020"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313029109063563"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913129109016264"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199107000-00005"},{"key":"e_1_2_3_8_2","article-title":"An immunohistochemical study of benign clear cell (\u2018sugar\u2019) tumor of the lung","volume":"115","author":"Gal AA","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90298-4"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000173232.22117.37"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00347.x"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880360"},{"key":"e_1_2_3_13_2","article-title":"Benign clear cell (\u2018sugar\u2019) tumors of the lung","volume":"43","author":"Liebow AA","year":"1963","journal-title":"Am J Pathol"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199606000-00010"},{"key":"e_1_2_3_15_2","article-title":"Malignant perivascular epithelioid cell tumor involving the prostate","volume":"127","author":"Pan CC","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200201000-00001"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200305000-00013"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880351"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01356.x"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200206000-00018"},{"key":"e_1_2_3_21_2","article-title":"Cutaneous clear cell myomelanocytic tumor\u2010perivascular epithelioid cell tumor: first reported case","volume":"16","author":"Crowson AN","year":"2003","journal-title":"Mod Pathol"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200412000-00017"},{"key":"e_1_2_3_23_2","unstructured":"FolpeAL.Neoplasms with perivascular epithelioid differentiation (PEComas). 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