{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:26:30Z","timestamp":1773469590404,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T00:00:00Z","timestamp":1204243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Previous studies suggest that chemokines and chemokine receptors have a role in the metastatic process. A correlation exists between the specific expression of these chemoattractive, pro\u2010inflammatory cytokines and the ability of cancer to disseminate. Prior studies have shown that in metastatic melanoma and squamous cell carcinoma of the head and neck upregulation of CXC (\u03b1) chemokine receptor (CXCR)4 and CC (\u03b2) chemokine receptor (CCR)7 expression is accompanied by downregulation of the chemokine receptor CCR6. However, the expression patterns of CCR6, CCR7 and CXCR4 in non\u2010melanoma skin cancer have yet to be elucidated.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The expression patterns of CCR6, CCR7 and CXCR4 were determined using an immunohistochemical approach on formalin\u2010fixed, paraffin\u2010embedded normal, pre\u2010cancerous actinic (solar) keratosis, squamous cell carcinoma and basal cell carcinoma tissues.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Analysis of chemokine receptor expression showed downregulation of CCR6 and upregulation of CCR7 and CXCR4 in potentially metastatic non\u2010melanoma skin cancer, invasive squamous cell carcinoma, but this pattern did not exist in non\u2010melanoma skin cancer with no metastatic potential, basal cell carcinoma; or actinic keratosis, when compared with normal skin.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Chemokine receptor expression may influence the biological behavior of non\u2010melanoma skin cancer. The exact mechanism by which this occurs requires further study.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00879.x","type":"journal-article","created":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T08:27:41Z","timestamp":1204273661000},"page":"623-629","source":"Crossref","is-referenced-by-count":15,"title":["Chemokine receptor expression in non\u2010melanoma skin cancer"],"prefix":"10.1111","volume":"35","author":[{"given":"Jeff","family":"Basile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Thiers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Sr.","given":"John","family":"Maize","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanne M. 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