{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T13:45:29Z","timestamp":1763387129735},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T00:00:00Z","timestamp":1208476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease, with some tendency toward malignant transformation. Markers are needed to identify the lesions at risk.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A series of 82 biopsies from 70 patients with atrophic OLP was analyzed for desmocollin\u20101, E\u2010cadherin, cyclin\u2010dependent kinase 1 (cdk\u20101) and Rad\u201051 expression using immunohistochemistry and static DNA cytometry, with particular reference to clinical outcome.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Desmocollin\u20101 and E\u2010cadherin expression were each detected in 24.4% (20\/82) of the samples. Of the positive samples, only eight specimens expressed both desmocollin\u20101 and E\u2010cadherin. Strong desmocollin\u20101 and E\u2010cadherin expression was found in 8.5% and 3.7% of OLP biopsies, respectively. Desmocollin\u20101 expression increased the risk of dysplasia 31.8\u2010fold (95% confidence intervals (CI) 3.6\u2013280.9; p\u2003=\u20030.0001), while E\u2010cadherin was significantly related to cancer (odds ratio (OR)\u2003=\u20035.13; 95% CI 3.3\u20138.1; p\u2003=\u20030.001). In univariate survival analysis, desmocollin\u20101 was a significant predictor of both cancer (log\u2010rank test; p\u2003=\u20030.033) and dysplasia (p\u2003=\u20030.0001), while E\u2010cadherin predicted the development of cancer (p\u2003=\u20030.0001). Neither cdk\u20101 nor Rad\u201051 had any predictive value. Importantly, desmocollin\u20101 retained its value as the only independent predictor of dysplasia in the multivariate (Cox) model (adjusted Hazard Ratio (HR)\u2003=\u200344.13; 95% CI 3.7\u2013525.6).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In atrophic OLP, desmocollin\u20101 is a powerful predictor of an important intermediate endpoint marker (dysplasia) in the causal pathway toward oral cancer.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00903.x","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T07:02:38Z","timestamp":1208502158000},"page":"832-838","source":"Crossref","is-referenced-by-count":12,"title":["Desmocollin expression in oral atrophic lichen planus correlates with clinical behavior and DNA content"],"prefix":"10.1111","volume":"35","author":[{"given":"Riikka","family":"Mattila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalle","family":"Alanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,7]]},"reference":[{"key":"e_1_2_6_2_2","article-title":"Definition of leukoplakia and related lesions: an aid to study precancer","volume":"46","author":"WHO. 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