{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:45:30Z","timestamp":1774226730168,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T00:00:00Z","timestamp":1215561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Psoriasis is a non\u2010contagious disorder that affects the skin as red scaly patches. Although the role of <jats:italic>Malassezia<\/jats:italic> species in the pathogenesis of psoriasis is still not fully understood, it is thought that these lipophilic yeasts might be a trigger factor in the exacerbation of psoriatic lesions.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Using culture in a specific medium followed by the polymerase chain reaction\u2010restriction fragment length polymorphism method, the presence of <jats:italic>Malassezia<\/jats:italic> species in the skin of 110 patients with psoriasis was compared with that in a control group of 123 healthy patients.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The recovery rate of <jats:italic>Malassezia<\/jats:italic> species from the skin of patients with psoriasis was significantly lower than that in the controls. In both psoriatic and healthy skin, <jats:italic>Malassezia globosa<\/jats:italic> was isolated as the predominant species. In psoriatic patients, the rate of colonization of <jats:italic>Malassezia furfur<\/jats:italic> and <jats:italic>Malassezia restricta<\/jats:italic> was almost twice that in the controls, whereas <jats:italic>M. globosa<\/jats:italic> was isolated more frequently from healthy individuals than from patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Considering the higher lipase activity secretion by <jats:italic>M. furfur<\/jats:italic> in comparison with other <jats:italic>Malassezia<\/jats:italic> species, the enzymatic release of arachidonic acid and its metabolites by <jats:italic>M. furfur<\/jats:italic> may exacerbate the inflammatory and hyperproliferative changes observed in psoriasis.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00968.x","type":"journal-article","created":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T12:58:31Z","timestamp":1215521911000},"page":"1027-1031","source":"Crossref","is-referenced-by-count":24,"title":["Distribution of 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