{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:38:03Z","timestamp":1779237483078,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T00:00:00Z","timestamp":1217808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The primary function of regulatory T cells (Treg cells) is to regulate the function and proliferation of immunologically responsive T cells; the transcription factor Foxp3 is expressed by this cell populace and is held to be the standard marker for Treg cells.<\/jats:p><jats:p><jats:bold>Design:\u2002<\/jats:bold> A variety of cutaneous T\u2010cell lymphocytic infiltrates were evaluated for Foxp3 expression.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the 95 cases, 33 (35%) were reactive, 40 (42%) were prelymphomatous cutaneous T\u2010cell dyscrasia and 22 were (23%) T\u2010cell lymphoma. The reactive category included dermatomyositis, lupus erythematosus, hypersensitivity reactions and graft\u2010vs.\u2010host disease. The prelymphomatous dyscrasia category was represented chiefly by pityriasis lichenoides chronica (PLC) and pigmented purpuric dermatosis (PPD). The Foxp3 reactivity was less than 10% for cases of dermatomyositis and lupus erythematosus, 23% for hypersensitivity cases, 0% for graft\u2010vs.\u2010host disease, 16% for the dyscrasias and 11% for the lymphomas. Intermediate grade and aggressive lymphomas had very few Foxp3+ cells (&lt;\u20035%). There were fewer numbers of Foxp3+ T cells in the monoclonal variants of PLC and PPD.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> T\u2010reg cells may play a role in controlling the extent of T\u2010cell proliferations in the skin with a lack of T\u2010regulatory function permissive to the development of various T\u2010cell disorders.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00969.x","type":"journal-article","created":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T08:35:16Z","timestamp":1217838916000},"page":"1032-1039","source":"Crossref","is-referenced-by-count":31,"title":["Foxp3 expression in cutaneous T\u2010cell lymphocytic infiltrates"],"prefix":"10.1111","volume":"35","author":[{"given":"Garron J.","family":"Solomon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia M.","family":"Magro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0019-2805.2003.01788.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.09.015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2004.apm1121001.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2004.apm1121002.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780059599"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03356.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200104)31:4<1122::AID-IMMU1122>3.0.CO;2-P"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090547"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068320"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01808.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.06.005"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8392"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2007.02.016"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7072"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00415.x"},{"key":"e_1_2_6_18_2","first-page":"36","article-title":"Foxp3 is required throughout the life of a regulatory T cell","volume":"393","author":"Lopes JE","year":"2007","journal-title":"Sci STKE"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.01.010"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1822"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-018218"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2181"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700371"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404182"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403965"},{"key":"e_1_2_6_26_2","first-page":"120","article-title":"Regulatory T\u2010cell function of adult T\u2010cell leukemia\/lymphoma cells","volume":"2007","author":"Yano H","year":"2052","journal-title":"Int J Cancer"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00080.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04999.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.01.06.db05-0340"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5115"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2007.00969.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2007.00969.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:30:45Z","timestamp":1697067045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2007.00969.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,10]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1111\/j.1600-0560.2007.00969.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2007.00969.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,10]]}}}