{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:37:48Z","timestamp":1790318268189,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T00:00:00Z","timestamp":1217808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Cutaneous lymphocyte\u2010associated antigen (CLA) is expressed in resident cutaneous T lymphocytes, high endothelial venules, peripheral monocytes, granulocytes and a small percentage of memory B cells. It has been postulated to be an important factor in homing of lymphocytes to the skin because of its function as a ligand for E\u2010selectin expressed on cutaneous endothelial cells.<\/jats:p><jats:p><jats:bold>Design:\u2002<\/jats:bold> We investigated the expression of CLA using the HECA\u2010452 antibody on paraffin\u2010embedded, formalin\u2010fixed tissue in a variety of reactive, neoplastic and preneoplastic cutaneous lymphoid infiltrates of T\u2010 and B\u2010cell derivation.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> CLA was expressed at high levels in various types of inflammatory dermatoses with the exception of lupus erythematosus. High levels of CLA expression were seen in epidermotropic T\u2010cell dyscrasias and epidermotropic T\u2010cell lymphomas including mycosis fungoides (MF) and adult T\u2010cell leukemia\/lymphoma (ATCLL). A loss of CLA in tumors normally positive for CLA was a feature of disease progression best exemplified by tumor\u2010stage MF and acute ATCLL. There was a lack of CLA expression in those lymphocytic infiltrates manifesting subcutaneous localization including lupus profundus, panniculitis\u2010like T\u2010cell lymphoma and atypical lymphocytic lobular panniculitis. CLA expression was not only observed in primary cutaneous anaplastic large cell lymphoma but also seen in cases of nodal anaplastic large cell lymphoma secondarily involving the skin and was negative in cases of nodal anaplastic large cell lymphoma without any established skin involvement. An oligodot pattern defined a novel reaction pattern in those aggressive systemic dyscrasias with a proclivity to involve the skin. CLA was negative in the majority of B\u2010cell lymphomas.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> CLA plays a role in the pattern of T\u2010cell lymphocyte migration in the skin and subcutis in both reactive and neoplastic states. An alteration in the expression of this marker, whether it is in the context of the acquisition of expression in a cell that is normally CLA negative or its loss of expression, may define a key event in determining cutaneous and extracutaneous hematopoietic cell distribution.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2007.00971.x","type":"journal-article","created":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T08:36:11Z","timestamp":1217838971000},"page":"1040-1049","source":"Crossref","is-referenced-by-count":29,"title":["Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B\u2010 and T\u2010cell lymphoid infiltrates"],"prefix":"10.1111","volume":"35","author":[{"given":"Cynthia M.","family":"Magro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly E.","family":"Dyrsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.5.1935"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.5.1485"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240132"},{"key":"e_1_2_7_5_2","first-page":"359","article-title":"Functional evidence that the HECA\u2010452 antigen is involved in the adhesion of human neutrophils and lymphocytes to tumour necrosis factor\u2010alpha\u2010stimulated endothelial cells","volume":"81","author":"De Boer OJ","year":"1994","journal-title":"Immunology"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/40166"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"14869","DOI":"10.1016\/S0021-9258(18)98555-8","article-title":"A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM\u20101","volume":"266","author":"Berg EL","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.2.241"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5230"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03608.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310007120"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.6.1461"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700199"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1552"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324311"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000049497"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.6.807"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.280704.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1309\/3N7P-J84L-JQ9K-G89R"},{"key":"e_1_2_7_20_2","first-page":"560","article-title":"Peripheral blood involvement in a mycosis fungoides patient with limited skin lesions: phenotypical features and homing molecule pattern","volume":"11","author":"Quaglino P","year":"2001","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01904.x"},{"key":"e_1_2_7_22_2","first-page":"553","article-title":"The comparison of expression of cutaneous lymphocyte\u2010associated antigen (CLA), and Th1\u2010 and Th2\u2010associated antigens in mycosis fungoides and cutaneous lesions of adult T\u2010cell leukemia\/lymphoma","volume":"13","author":"Yamaguchi T","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03607.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.7.921"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1001\/archderm.1993.01680310094017","article-title":"Interface dermatitis. How specific are its histopathologic features?","volume":"129","author":"LeBoit PE","year":"1993","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.3.361"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.6_Pt_2.S47"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.6.3417"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290804.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.10.5860"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_7_32_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2340\/00015555763436","article-title":"Stage\u2010dependent expression of CD7, CD45RO, CD45RA and CD25 on CD4\u2010positive peripheral blood T\u2010lymphocytes in cutaneous T\u2010cell lymphoma","volume":"76","author":"Jakob T","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901201)66:11<2380::AID-CNCR2820661122>3.0.CO;2-H"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.7.889"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1309\/0QPPAVTUPCV9UCLV"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028005256.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19610.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2007.00971.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2007.00971.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:31:19Z","timestamp":1697067079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2007.00971.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,10]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1111\/j.1600-0560.2007.00971.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2007.00971.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,10]]}}}