{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:25:12Z","timestamp":1792113912348,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T00:00:00Z","timestamp":1212969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>Although trichoepitheliomas (TEs) are commonly regarded as benign tumors of follicular origin, the natural history of multiple familial trichoepitheliomas (MFT) and their risk for malignancy has been unclear. We describe a 57\u2010year\u2010old male with numerous skin\u2010colored firm papules and plaques present on the central face since 6\u2003years of age. Recently, some lesions had enlarged and ulcerated. Other family members were similarly affected. Biopsies from multiple lesions showed TEs both alone and associated with basal cell carcinoma (BCC) in the same section, suggesting the secondary development of BCCs within TEs. Many prior reports of BCCs arising within TEs in patients with presumed MFT were likely misdiagnosed cases of nevoid BCC. This report is a compelling example of MFT in which BCCs evolved secondarily. Awareness of the potential for the evolution of carcinoma in patients with MFT is important in the management of these patients.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2008.01002.x","type":"journal-article","created":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T03:56:07Z","timestamp":1213070167000},"page":"59-64","source":"Crossref","is-referenced-by-count":29,"title":["Basal cell carcinomas arising within multiple trichoepitheliomas"],"prefix":"10.1111","volume":"35","author":[{"given":"Laura B.","family":"Pincus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.","family":"McCalmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac M.","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis H.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,29]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000254425"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1986.tb01510.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70046-V"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.133.5.666"},{"key":"e_1_2_4_6_2","first-page":"221","article-title":"Multiple trichoepithelioma with basal cell carcinoma","volume":"43","author":"Yamamoto N","year":"1999","journal-title":"Ann Plast Surg"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051650"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200210000-00005"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1975.tb00113.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archderm.1994.01690050057008","article-title":"CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma","volume":"130","author":"Kirchmann TT","year":"1994","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08453.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb00780.x"},{"key":"e_1_2_4_13_2","first-page":"459","article-title":"Multiple benign cystic epithelioma of the skin","volume":"10","author":"Fordyce JA","year":"1892","journal-title":"J Cutan Genitourin Dis"},{"key":"e_1_2_4_14_2","first-page":"269","article-title":"Epithelioma adenoides cysticum","volume":"4","author":"Brooke HG","year":"1892","journal-title":"Br J Dermatol"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590130108018"},{"key":"e_1_2_4_16_2","volume-title":"Neoplasms with follicular differentiation","author":"Ackerman AB","year":"2001"},{"key":"e_1_2_4_17_2","first-page":"1733","volume-title":"Dermatology","author":"McCalmont T","year":"2003"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01708.x"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.5.616"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199908000-00004"},{"key":"e_1_2_4_21_2","volume-title":"Skin pathology","author":"Weedon D","year":"2002"},{"key":"e_1_2_4_22_2","first-page":"479","article-title":"Tumors of the hair follicle. 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