{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:41:26Z","timestamp":1775594486557,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,8,24]],"date-time":"2008-08-24T00:00:00Z","timestamp":1219536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>We report two cases of hydroxychloroquine\u2010induced hyperpigmentation presenting in a 50\u2010year\u2010old Caucasian female (case 1) and a 78\u2010year\u2010old female (case 2), both receiving 400\u2003mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4\u20135\u2003years. She presented with a mottled, reticulated macular gray pigmentation involving the upper back and shoulders. Case 2 had a history of systemic lupus erythematosus and rheumatoid arthritis, treated with hydroxychloroquine for 1.5\u2003years. She presented to the hospital for treatment of constrictive cardiomyopathy and was noted to have a blue macular pigmentation involving the right temple. The biopsies from both patients showed superficial dermal, yellow\u2010brown, non\u2010refractile and coarsely granular pigment deposition. A Fontana\u2010Masson stain highlighted some of these granules, while the Perl\u2019s iron stain was negative. Rare, previous reports of hyperpigmentation indicate the presence of both melanin and hemosiderin in patients being treated with antimalarial medication. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to melanin.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2008.01004.x","type":"journal-article","created":{"date-parts":[[2008,8,25]],"date-time":"2008-08-25T01:15:19Z","timestamp":1219626919000},"page":"1134-1137","source":"Crossref","is-referenced-by-count":42,"title":["Hydroxychloroquine\u2010induced hyperpigmentation: the staining pattern"],"prefix":"10.1111","volume":"35","author":[{"given":"Puja K.","family":"Puri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nektarios I.","family":"Lountzis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammie","family":"Ferringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,30]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb07496.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rhu.0000260649.36417.09"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb02689.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590220051006"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102040-00006"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01168-5"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70072-0"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90035-1"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10278"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01412.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01494.x"},{"key":"e_1_2_4_13_2","first-page":"281","article-title":"Pigmentation of the gums following hydroxychloroquine therapy","volume":"49","author":"Veraldi S","year":"1992","journal-title":"Cutis"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2008.01004.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2008.01004.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:06:11Z","timestamp":1697069171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2008.01004.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,30]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1111\/j.1600-0560.2008.01004.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2008.01004.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,30]]}}}