{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:25:13Z","timestamp":1778498713966,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,21]],"date-time":"2008-07-21T00:00:00Z","timestamp":1216598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Spiradenoma (Sp) is a rare adnexal cutaneous tumor with a prominent vasculature. There are few reports in the literature suggesting that the majority of the cases contain perivascular spaces with numerous lymphocytes, a feature that is characteristic in thymus neoplasms. However, there is little information available about the nature and maturity of the lymphocytes comprising these spaces.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We report a case of a Sp that presented as a palpable painless mass in a 45\u2010year\u2010old woman and had histological similarities with thymomas. Furthermore, we compare these two entities in detail, discussing the differences and possible similarities between them.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> On histological grounds, the lesion consisted of epithelial lobules with prominent ductal differentiation admixed with conspicuous perivascular spaces containing numerous lymphocytes. Immunohistochemical analysis showed that perivascular spaces contained mostly T lymphocytes (CD3 positive), which in contrast with those seen in most thymomas were mature (CD99, CD1a and Terminal deoxynucleotidyl transferase (Tdt) negative). A detailed comparison between Sps and thymomas shows that there exist several important clinicopathological and cytological differences between these two tumors.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> We suggest that the resemblance between Sps and thymomas is strictly architectural, and we raise some questions regarding the role of these perivascular spaces in tumor development.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2008.01009.x","type":"journal-article","created":{"date-parts":[[2008,7,21]],"date-time":"2008-07-21T07:29:14Z","timestamp":1216625354000},"page":"246-250","source":"Crossref","is-referenced-by-count":2,"title":["Spiradenoma reminiscent of thymoma: report of a case and review of the literature"],"prefix":"10.1111","volume":"36","author":[{"given":"Georgia","family":"Levidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Lazaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina","family":"Androulaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,20]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2003.0412"},{"key":"e_1_2_4_3_2","volume-title":"Pathology of the skin with clinical correlations","author":"McKee PH","year":"2005"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000074499.01431.61"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00556.x"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2006.21.1.172"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199506000-00009"},{"key":"e_1_2_4_8_2","first-page":"49","article-title":"The fine structure of thymoma, with emphasis on its differential diagnosis. 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