{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T16:22:08Z","timestamp":1715962928238},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T00:00:00Z","timestamp":1224460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Pityriasis lichenoides (PL) is an inflammatory skin disease of unknown etiology. Nitric oxide (NO) has emerged as an important mediator of many physiological functions. The importance of NO\u2010mediated signaling in skin diseases has been reported by several studies.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A review of clinical records and histopathological slides of 34 patients diagnosed with PL was performed. Three different groups of skin biopsies including PL chronica (24 patients), PL et varioliformis acuta (10 patients) and 15 normal skin samples were subjected to the immunohistochemistry technique for inducible nitric oxide synthase (iNOS) detection.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Normal skin group exhibited a few number of iNOS\u2010positive cells in the dermis and rare positive cells in the upper epidermis, unlike abundant epidermal and dermal iNOS expression observed in both PL groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> According to our results, we hypothesize that NO produced by iNOS could participate in PL pathogenesis. Abnormal and persistent responses to unknown antigens, probably a pathogen, associated with NO immunoregulatory functions could contribute to the relapsing course observed in PL. NO anti\u2010apoptotic effect on T\u2010cell lymphocytes could play a role on maintenance of reactive T cells, leading to a T\u2010cell lymphoid dyscrasia.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2008.01028.x","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T22:46:20Z","timestamp":1233269180000},"page":"325-330","source":"Crossref","is-referenced-by-count":1,"title":["Inducible nitric oxide synthase in pityriasis lichenoides lesions"],"prefix":"10.1111","volume":"36","author":[{"given":"Gabriella","family":"Di Giunta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Gon\u00e7alves da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirian N.","family":"Sotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.1998.1998015001.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.058"},{"key":"e_1_2_5_4_2","first-page":"305","article-title":"Differentiation and clonality of lesional lymphocytes in pityriasis lichenoides chronica","volume":"137","author":"Shieh S","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70094-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02650.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb01097.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb02531.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01301.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.337"},{"key":"e_1_2_5_11_2","first-page":"121","article-title":"Varicella\u2010zoster virus involved in the etiopathogeny of pityriasis lichenoides?","author":"Boralevi F","year":"2003","journal-title":"J Invest Dermatol"},{"key":"e_1_2_5_12_2","first-page":"31","article-title":"Pityriasis lichenoides: a cytotoxic T\u2010cell mediated skin disorder. 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