{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:24:11Z","timestamp":1788546251934,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,10,6]],"date-time":"2008-10-06T00:00:00Z","timestamp":1223251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>Classic Paget\u2019s disease (PD) can be diagnosed relatively easily by histopathologic examination. \u2018Anaplastic\u2019 variant of this disease is a less\u2010recognized subset that may pose as a diagnostic challenge and pitfall. We describe two cases who presented with scaly erythematous plaques on their nipple\/areola. In the first patient, there was no palpable mass and imaging studies were negative. The second case presented with a lesion 5\u2003years after a lumpectomy. Initial shave biopsies revealed histopathologic changes indistinguishable from Bowen\u2019s disease with no readily identifiable classic Paget\u2019s cells, associated with prominent superficial acantholysis. The neoplastic cells were negative for mucin, GCDFP\u201015, negative\/minimally positive for CEA and strongly positive for CK7 markers. A high\u2010grade ductal carcinoma <jats:italic>in situ<\/jats:italic> in the underlying breast was ultimately found in both cases. Anaplastic PD is a rare variant of this disease that histologically mimics Bowen\u2019s disease with an associated prominent superficial acantholysis. There is mucin, CEA and GCDFP\u201015 negativity with positive CK7 reaction. A high index of suspicion along with a complete immunohistochemical panel should be considered in evaluating any Bowenoid neoplasm of the breast skin, particularly in superficial skin shave biopsies along with negative imaging studies and no palpable mass clinically.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2008.01053.x","type":"journal-article","created":{"date-parts":[[2008,10,6]],"date-time":"2008-10-06T09:05:34Z","timestamp":1223283934000},"page":"374-380","source":"Crossref","is-referenced-by-count":16,"title":["Acantholytic anaplastic Paget\u2019s disease"],"prefix":"10.1111","volume":"36","author":[{"given":"Narciss","family":"Mobini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"87","article-title":"On disease of the mammary areola preceding cancer of the mammary gland","volume":"10","author":"Paget 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