{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:46:18Z","timestamp":1784997978207,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Silver dressings have been widely and successfully used to prevent cutaneous wounds, including burns, chronic ulcers, dermatitis and other cutaneous conditions, from infection. However, in a few cases, skin discolouration or argyria\u2010like appearances have been reported. This study investigated the level of silver in scar tissue post\u2010burn injury following application of Acticoat\u2122, a silver dressing.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A porcine deep dermal partial thickness burn model was used. Burn wounds were treated with this silver dressing until completion of re\u2010epithelialization, and silver levels were measured in a total of 160 scars and normal tissues.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The mean level of silver in scar tissue covered with silver dressings was 136\u2003\u03bcg\/g, while the silver level in normal skin was less than 0.747\u2003\u03bcg\/g. A number of wounds had a slate\u2010grey appearance, and dissection of the scars revealed brown\u2010black pigment mostly in the middle and deep dermis within the scar. The level of silver and the severity of the slate\u2010grey discolouration were correlated with the length of time of the silver dressing application.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results show that silver deposition in cutaneous scar tissue is a common phenomenon, and higher levels of silver deposits and severe skin discolouration are correlated with an increase in the duration of this silver dressing application.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2008.01141.x","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T08:07:34Z","timestamp":1243843654000},"page":"788-792","source":"Crossref","is-referenced-by-count":41,"title":["Silver deposits in cutaneous burn scar tissue is a common phenomenon following application of a silver dressing"],"prefix":"10.1111","volume":"36","author":[{"given":"Xue\u2010Qing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010En","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Olszowy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Cuttle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Kravchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gael E.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy M.","family":"Kimble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.08.043"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3274-8.50014-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00152192-200609000-00003"},{"key":"e_1_2_6_5_2","article-title":"The effect of a silver\u2010containing hydrofiber dressing on superficial wound bed and bacterial balance of chronic wounds","volume":"2","author":"Coutts P","year":"2005","journal-title":"Int Wound 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