{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:51:36Z","timestamp":1762505496040},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T00:00:00Z","timestamp":1245628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>Microscopic polyangiitis (MPA) can be distinguished from Henoch\u2010Schoenlein purpura (HSP) based on the presence of renal\u2010pulmonary complications, myeloperoxidase\u2010antineutrophil cytoplasmic antibody (MPO\u2010ANCA) seropositivity and pauci\u2010immune glomerulonephritis; these characteristics of MPA are generally not found in HSP. Here, we present a unique case with MPA and HSP overlapping syndrome. A 74\u2010year\u2010old man presented with a skin rash accompanied by intracranial bleeding, acute renal failure and pulmonary hemorrhage resulting in a fatal outcome. An autopsy revealed the marked formation of crescentic glomerulonephritis, diffuse pulmonary alveolar hemorrhage and focal cerebral bleeding. Histological features showing both dermal small\u2010vessel vasculitis and cutaneous polyarteritis nodosa\u2010like arteritis suggested MPA rather than HSP, in which the dermal small vessels are exclusively affected. Meanwhile, capillary immunoglobulin (Ig)A deposits in the skin and glomeruli suggested HSP.<\/jats:p><jats:p>As MPA and HSP overlapping syndrome characterized by the synergistic effect of MPO\u2010ANCA and the IgA immune complex may result in a fatal outcome, aggressive immunosuppressive therapy should be initiated as early as possible.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2008.01145.x","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T10:39:52Z","timestamp":1245667192000},"page":"871-877","source":"Crossref","is-referenced-by-count":18,"title":["MPO\u2010ANCA\u2010 and IgA\u2010positive systemic vasculitis: a possibly overlapping syndrome of microscopic polyangiitis and Henoch\u2010Schoenlein purpura"],"prefix":"10.1111","volume":"36","author":[{"given":"Takeshi","family":"Nagasaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyuria","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kon Ron","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,22]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69114-9"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0136-1"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711203372106"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91341-5"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000013883.99976.22"},{"key":"e_1_2_4_7_2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/archderm.1997.03890400034005","article-title":"Schonlein\u2010Henoch purpura in adult patients. 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