{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:53Z","timestamp":1761058913677},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:00:00Z","timestamp":1237248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Molluscum contagiosum (MC) is a Molluscipox virus infection of keratinocytes with hyperplasia and intracytoplasmic inclusions\u2014the molluscum bodies (MBs). Few papers address cytokeratins (K) profile in MC, mainly focusing terminal keratinization process.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Forty\u2010one MC lesions were subjected to immunohistochemical technique to verify K1, K10, K14, K16, involucrin, filaggrin, E\u2010cadherin and p63 expression. MC immunolabeling pattern was compared to adjacent normal appearing epidermis (ANAE).<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> In MC and ANAE, K1\/K10 were expressed in suprabasal layers, K14 was expressed in basal and suprabasal layers and K16 was expressed through all spinous layer. Involucrin and filaggrin were observed in granular, spinous and in basal layer of ANAE and MC. E\u2010cadherin was present up to the first layers of MC while ANAE exhibited E\u2010cadherin labeling at basal and spinous layers. Basal and spinous layers keratinocytes nuclei, in both MC and ANAE, express p63.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Infection by Molluscipox virus alters keratinocyte differentiation status. The presence of K14 and p63 in spinous layer, as well as early expression of involucrin and filaggrin, associated to a hyperproliferative state disclosed by K16 expression, may be a result of disruption in keratinocytes maturation process. The changes observed at ANAE may represent early events in keratinization disturbance.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2009.01288.x","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T02:42:16Z","timestamp":1237344136000},"page":"1279-1285","source":"Crossref","is-referenced-by-count":10,"title":["Molluscum contagiosum: immunomorphological aspects of keratinocytes markers of differentiation and adhesion"],"prefix":"10.1111","volume":"36","author":[{"given":"Clarissa Freitas","family":"Callegaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirian N.","family":"Sotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,26]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.035"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.109302"},{"key":"e_1_2_9_4_2","first-page":"202","article-title":"Molluscum contagiosum: the need for physician intervention and new treatment options","volume":"73","author":"Bikowski JB","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70012-5"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90400-7"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200603161"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.300102.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0859-2"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00413355"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb03271.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02930.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750011336"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00677.x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1619"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02696.x"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb06912.x"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2005.00086.x"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962004000600004"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb02818.x"},{"key":"e_1_2_9_22_2","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1242\/jcs.112.24.4569","article-title":"Inhibition of cadherin function differentially affects markers of terminal differentiation in cultured human keratinocytes","volume":"112","author":"Hines MD","year":"1999","journal-title":"J Cell Sci"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152059399"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2003.10.003"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2009.01288.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2009.01288.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:11:57Z","timestamp":1696968717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2009.01288.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,26]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1111\/j.1600-0560.2009.01288.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2009.01288.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,26]]}}}