{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:56:42Z","timestamp":1785783402307,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T00:00:00Z","timestamp":1247184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Malignant eccrine spiradenoma is an extremely rare skin tumor of sweat gland origin. In most cases, it arises in pre\u2010existing benign eccrine spiradenoma.<\/jats:p><jats:p>We report an additional case of malignant eccrine spiradenoma. The present case is of a 75\u2010year\u2010old man with malignant eccrine spiradenoma developed in the right shoulder. He had a 6\u2010year history of a recurrent mass that was removed 2 years ago. The patient then underwent a complete excision. The gross pathologic specimen showed a large cutaneous and subcutaneous multinodular tumor, measuring 6 cm in maximal dimension. Microscopically, there were two distinct morphological components: a benign eccrine spiradenoma and a malignant eccrine spiradenoma of low grade with extensive necrosis. Different histologic patterns were observed such as cylindromatous features.<\/jats:p><jats:p>Morphological differentiation in malignant eccrine spiradenoma is variable, sometimes with almost complete loss of eccrine differentiation. Extensive sampling to look for a probable previously benign component is necessary. In the other hand, malignant changes can be easily missed without adequate sampling.<\/jats:p><jats:p>Ben Brahim E, Sfia M, Tangour M, Makhlouf R, Cribier B, and Chatti S. Malignant eccrine spiradenoma: a new case report<\/jats:p>","DOI":"10.1111\/j.1600-0560.2009.01320.x","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T11:30:36Z","timestamp":1247225436000},"page":"478-481","source":"Crossref","is-referenced-by-count":23,"title":["Malignant eccrine spiradenoma: a new case report"],"prefix":"10.1111","volume":"37","author":[{"given":"Ehsen","family":"Ben Brahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Sfia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Tangour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridha","family":"Makhlouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cribier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Chatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,11]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"388","article-title":"Malignant transformation of eccrine spiradenoma","volume":"11","author":"Dabska M.","year":"1972","journal-title":"Pol Med J"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.5858\/2002-126-0591-MES"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00608.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.5858\/2001-125-0498-COSG","article-title":"Carcinoma of sweat glands: report of 60 cases","volume":"125","author":"Urso C","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_6_2","first-page":"501","article-title":"Carcinosarcoma arising in eccrine spiradenoma of the breast","volume":"120","author":"Saboorian MH","year":"1996","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08138.x"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200004000-00002"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1985.01660110093023"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199210000-00002"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199008000-00002"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01609.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2001.25407"},{"key":"e_1_2_4_14_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archderm.1982.01650160063026","article-title":"Cylindroma and eccrine spiradenoma coexistent in the same lesion","volume":"118","author":"Goette DK","year":"1982","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00265.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.1999.00890.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2009.01320.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2009.01320.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T09:35:36Z","timestamp":1698744936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2009.01320.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,11]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1111\/j.1600-0560.2009.01320.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2009.01320.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,11]]}}}