{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:01:29Z","timestamp":1776506489599,"version":"3.51.2"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T00:00:00Z","timestamp":1247443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold> Tumors of the lacrimal sac are rare but noteworthy because of their significant potential to become malignant or life\u2010threatening if treatment is delayed. Dermatologists may be the first to encounter such neoplasms.<\/jats:p><jats:p> <jats:bold>Observations:<\/jats:bold> We report a case of a 53\u2010year\u2010old Caucasian woman who presented with a seven\u2010year history of an asymptomatic, subcutaneous nodule near her right medial canthus. Histology of the lesion revealed transitional epithelium in a papillary growth pattern with numerous goblet cells, scattered mitoses and focal full\u2010thickness atypia. The patient was diagnosed with transitional cell neoplasm (inverted papilloma\u2010type) of the nasolacrimal duct. PCR evaluation identified HPV type 11 in the lesion.<\/jats:p><jats:p> <jats:bold>Conclusion:<\/jats:bold> Our report is one of a growing number of case reports and series detecting HPV DNA in these tumors which further supports HPV as an etiologic agent in epithelial lacrimal sac tumors. We believe that dermatopathologists need to be aware of this entity, as dermatologists may be the first to encounter these neoplasms.<\/jats:p><jats:p> <jats:bold>Limitations:<\/jats:bold> The association of HPV with this tumor does not prove causality.<\/jats:p><jats:p>Vickers JL, Matherne RJ, Allison AW, Wilkerson MG, Tyring SK, Bartlett BL, Rady PL, Kelly BC. Transitional cell neoplasm of the nasolacrimal duct associated with human papillomavirus type.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2009.01351.x","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T10:40:17Z","timestamp":1247481617000},"page":"793-796","source":"Crossref","is-referenced-by-count":12,"title":["Transitional cell neoplasm of the nasolacrimal duct associated with human papillomavirus type 11"],"prefix":"10.1111","volume":"37","author":[{"given":"Jennifer L.","family":"Vickers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Matherne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley W.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Wilkerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen K.","family":"Tyring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda L.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"Rady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent C.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,18]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.18.1477"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2004.08.007"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700516"},{"key":"e_1_2_3_5_2","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.5858\/2005-129-1493-AMOTRL","article-title":"A Mass of the Right Lacrimal Sac in a 53\u2010year\u2010old Man","volume":"129","author":"Pang C","year":"2005","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2007.00893.x"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200103000-00001"},{"key":"e_1_2_3_8_2","first-page":"4375","article-title":"P16(INK4a) correlates to human papillomavirus presence, response to radiotherapy and clinical outcome in tonsillar carcinoma","volume":"25","author":"Mellin Dahlstrand H","year":"2005","journal-title":"Anticancer Research"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1130>3.0.CO;2-0"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.5.2620-2626.2004"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147918.81733.49"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-106"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2009.01351.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2009.01351.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:55:44Z","timestamp":1698731744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2009.01351.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,18]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1111\/j.1600-0560.2009.01351.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2009.01351.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,18]]}}}