{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T18:55:58Z","timestamp":1743101758850},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T00:00:00Z","timestamp":1266451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p> <jats:bold>Background:<\/jats:bold> Proper diagnosis of myeloid leukemia cutis (LC) is of great clinical importance but can be difficult because no single immunohistochemical marker is adequately sensitive or specific for definitive diagnosis. Thus, a broader panel of markers is often desirable. CD163 is highly specific for normal and neoplastic cells of the monocyte\/histiocyte lineage. In this study, we examined the value of CD163 in the diagnosis of acute myeloid LC.<\/jats:p><jats:p> <jats:bold>Methods:<\/jats:bold> A total of 34 cases, including 18 cases of myelomonocytic or monocytic LC, 10 cases of myeloid LC without monocytic component and 6 cases of acute lymphoblastic leukemia\/lymphoma (ALL), were stained with CD163.<\/jats:p><jats:p> <jats:bold>Results:<\/jats:bold> CD163 was expressed in 8 of 18 (44%) of myelomonocytic or monocytic LC and 1 of 10 (10%) of other myeloid LC, but in none of the ALL cases (0\/6). CD163 was highly specific (90%) for myeloid LC with a monocytic component, but showed low sensitivity in the diagnosis of both myeloid LC in general (24%) and myeloid LC with a monocytic component (44%).<\/jats:p><jats:p> <jats:bold>Conclusions:<\/jats:bold> Our results suggest that CD163 has utility as a specific marker for myeloid LC in conjunction with currently used immunohistochemical stains, but should not be used alone for diagnosis.<\/jats:p><jats:p>Harms PW, Bandarchi B, Ma L. 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