{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:18:34Z","timestamp":1792124314790,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T00:00:00Z","timestamp":1322524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Secondary angiosarcoma and benign but microscopically atypical vascular proliferations (herein referred to as atypical vascular lesion or AVL) are rare consequences of radiation therapy and\/or chronic lymphedema most commonly seen in breast cancer patients. Differentiating angiosarcoma from AVL can be difficult due to overlapping clinical and microscopic features. Recently, amplification of <jats:italic>MYC<\/jats:italic> has been associated with 55\u2013100% of secondary angiosarcomas but is reportedly absent in AVL. We examined a series of secondary angiosarcoma and AVL for <jats:italic>MYC<\/jats:italic> amplification by fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) and expression by immunohistochemistry to investigate the diagnostic utility for discriminating angiosarcoma from AVL.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Cases of secondary angiosarcoma (n = 8) and AVL (n = 4) were retrieved from our archives and examined by FISH and immunohistochemistry.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All angiosarcoma cases (8\/8 = 100%) demonstrated high\u2010level <jats:italic>MYC<\/jats:italic> amplification by FISH, whereas all AVLs (0\/4 = 0%) were negative for <jats:italic>MYC<\/jats:italic> amplification. Additionally, all angiosarcoma cases (8\/8 = 100%) demonstrated nuclear positivity for MYC, whereas all AVLs (0\/4 = 0%) were negative.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Amplification of <jats:italic>MYC<\/jats:italic> and nuclear expression of MYC is present in secondary angiosarcoma but not AVL. These ancillary tests can be useful to distinguish angiosarcoma from AVL in difficult cases.<\/jats:p><jats:p>Fernandez AP, Sun Y, Tubbs RR, Goldblum JR, Billings SD. FISH for MYC amplification and anti\u2010MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2011.01843.x","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T12:59:52Z","timestamp":1322657992000},"page":"234-242","source":"Crossref","is-referenced-by-count":117,"title":["FISH for MYC amplification and anti\u2010MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations"],"prefix":"10.1111","volume":"39","author":[{"given":"Anthony P.","family":"Fernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond 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