{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:29:56Z","timestamp":1772839796089,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T00:00:00Z","timestamp":1323907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Cutaneous leishmaniasis displays considerable variation in its histopathological and clinical presentation. Clinically, it progresses from a papule into a painless ulcerated and crusted nodule\/papule. Microscopically, it progresses from sheets of amastigote\u2010filled histiocytes to granulomatous inflammation.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>The study was conducted on 145 skin biopsies from untreated patients with histopathological and\/or clinical suspicion of cutaneous leishmaniasis in Lebanon, Syria and Saudi Arabia (1992\u20132010). The pre\u2010biopsy clinical diagnosis and demographic data were collected. Biopsies were evaluated for the major microscopic pattern, and the parasitic index (PI) was also determined. Diagnosis was confirmed by polymerase chain reaction (PCR) followed by molecular sub\u2010speciation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Of the 145 patients, 125 were confirmed as cutaneous leishmaniasis by PCR. Eighteen cases presented with a pre\u2010biopsy clinical diagnosis other than cutaneous leishmaniasis that ranged from dermatitis to neoplasm. Of the 125 cases, 57 showed a major histopathological pattern other than cutaneous leishmaniasis. Identification of amastigotes was equivocal (PI \u22641) in 38 of the 57 cases. Of interest, all the 18 cases with a pre\u2010biopsy clinical diagnosis other than cutaneous leishmaniasis also showed atypical histopathology for cutaneous leishmaniasis.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold>The manifestations of cutaneous leishmaniasis are broad and may mimic other inflammatory and neoplastic diseases. Pathologists and dermatologists should be aware of such pitfalls and can utilize PCR to confirm the diagnosis of leishmaniasis.<\/jats:p><jats:p>Saab J, Fedda F, Khattab R, Yahya L, Loya A, Satti M, A\u2010G Kibbi, Houreih MA, Raslan W, El\u2010Sabban M, Khalifeh I. Cutaneous leishmaniasis mimicking inflammatory and neoplastic processes: a clinical, histopathological and molecular study of 57 cases.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2011.01844.x","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T07:27:32Z","timestamp":1323934052000},"page":"251-262","source":"Crossref","is-referenced-by-count":43,"title":["Cutaneous leishmaniasis mimicking inflammatory and neoplastic processes: a clinical, histopathological and molecular study of 57 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