{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:49:26Z","timestamp":1772160566915,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:00:00Z","timestamp":1330992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    T cells expressing the \u03b3\u03b4 T\u2010cell receptor (TCR) (\u03b3\u03b4 T cells) are found in normal epithelial tissues such as the skin. However, the proportions of \u03b3\u03b4 T cells that may be observed in commonly encountered cutaneous diseases with a prominent lymphocytic infiltrate have not been elucidated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Our pathology database was searched for cases of mycosis fungoides, erythema multiforme, graft\u2010versus\u2010host disease, lichen planus, lupus panniculitis and spongiotic dermatitis. Immunostaining for CD3, \u03b2F1 and the TCR \u03b3 chain was performed on formalin\u2010fixed paraffin\u2010embedded specimens retrieved from these cases to determine the normal range of \u03b3\u03b4 T cells in these diseases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In 100 of the 101 cases studied (99.0%), \u03b3\u03b4 T cells accounted for less than 10% of the T\u2010cell infiltrate. Furthermore, \u03b3\u03b4 T cells were essentially absent in 74 cases (73.3%).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These results suggest that \u03b3\u03b4 T cells very rarely account for more than 10% of the lymphocytic infiltrate in common inflammatory or infiltrative processes of the skin. Any case of suspected mycosis fungoides or interface dermatitis that possesses more than 10% \u03b3\u03b4 T cells should raise consideration for further investigation.\n                  <\/jats:p>\n                  <jats:p>Hocker TL, Wada DA, el\u2010Azhary R, Gibson LE. Expression of T\u2010cell receptor\u2010\u03b3\u03b4 in normal human skin, dermatitis and mycosis fungoides.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2011.01859.x","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T00:40:38Z","timestamp":1330994438000},"page":"419-424","source":"Crossref","is-referenced-by-count":12,"title":["Expression of T\u2010cell receptor\u2010\u03b3\u03b4 in normal human skin, inflammatory dermatoses and mycosis fungoides"],"prefix":"10.1111","volume":"39","author":[{"given":"Thomas L.","family":"Hocker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rokea","family":"el\u2010Azhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence E.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/322145a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/343754a0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/323638a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00474.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1828619"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030584"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7973709"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.6553"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063916"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1390"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30989"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20012000"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03162.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.6.2167"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.169"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPMG37MXKYPUBE"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01741.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.029"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327932"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2011.01859.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2011.01859.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:29:52Z","timestamp":1698701392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2011.01859.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,6]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1600-0560.2011.01859.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2011.01859.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.715397801.790902901","asserted-by":"object"}]},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,6]]}}}