{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:25:39Z","timestamp":1766269539173},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T00:00:00Z","timestamp":1328918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>In lymph nodes, classical Hodgkin lymphoma can typically be distinguished from non\u2010Hodgkin lymphoma (NHL) by the presence of Hodgkin and Reed\u2010Sternberg cells that co\u2010express CD30 and CD15. However, anaplastic large cell lymphoma (ALCL) and diffuse large B\u2010cell lymphoma (DLBCL) can show identical features, and some cases of classical Hodgkin lymphoma lack CD15 expression, rendering them difficult to differentiate from CD30\u2010positive NHL. The differential diagnosis of cutaneous Hodgkin lymphoma similarly includes ALCL and DLBCL, and, additionally, tumors of mycosis fungoides. Recent studies have shown that classical Hodgkin lymphoma is of B\u2010cell origin in virtually all cases, and shows at least focal weak expression of the B\u2010cell marker PAX5 and often focal weak expression and no expression of the B\u2010cell markers Oct\u20102 and BOB.1, respectively. All three of these markers are almost invariably absent in T\u2010cell lymphomas and are strongly expressed in B\u2010cell lymphomas. We report a 40\u2010year\u2010old man with classical Hodgkin lymphoma who developed cutaneous nodules. A biopsy from one revealed Hodgkin\/Reed\u2010Sternberg cells with a similar immunophenotype to the diagnostic lymph node biopsy, namely CD30+\/CD15+, diffusely but weakly PAX5+, focally weakly Oct\u20102+ and lacking BOB.1 expression, thereby confirming a diagnosis of cutaneous Hodgkin lymphoma. To our knowledge, this is the first report of the expression pattern of the combination of PAX5, Oct\u20102 and BOB.1 in the context of cutaneous involvement by Hodgkin lymphoma.<\/jats:p><jats:p>Cho RJ, McCalmont TH, Ai WZ, Fox LP, Treseler P, Pincus LB. Case report demonstrating use of an expanded immunohistochemical panel to distinguish cutaneous Hodgkin lymphoma from histopathologic imitators.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2012.01872.x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T18:53:33Z","timestamp":1326221613000},"page":"651-658","source":"Crossref","is-referenced-by-count":13,"title":["Use of an expanded immunohistochemical panel to distinguish cutaneous Hodgkin lymphoma from histopathologic imitators"],"prefix":"10.1111","volume":"39","author":[{"given":"Raymond J.","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy H.","family":"McCalmont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyun Z.","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindy P.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Treseler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura B.","family":"Pincus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1309\/YCH8DWUFFQBKGPVB"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"3108.","DOI":"10.1182\/blood.V94.9.3108","article-title":"Frequent expression of the B\u2010cell\u2010specific activator protein in Reed\u2010Sternberg cells of classical Hodgkin's disease provides further evidence for its B\u2010cell origin.","volume":"94","author":"Foss HD","year":"1999","journal-title":"Blood"},{"key":"e_1_2_5_4_2","first-page":"345.","article-title":"Expression of T\u2010cell antigens on Reed\u2010Sternberg cells in a subset of patients with nodular sclerosing and mixed cellularity Hodgkin's disease.","volume":"130","author":"Kadin ME","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800276"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.10962"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510053331403"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.6.2662"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.9.1589"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200210000-00011"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800227"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/319154a0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880518"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200002)30:2<458::AID-IMMU458>3.0.CO;2-5"},{"key":"e_1_2_5_15_2","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissue","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"441.","DOI":"10.5858\/2008-132-441-AOIITD","article-title":"Application of immunohistochemistry in the diagnosis of non\u2010Hodgkin and Hodgkin lymphoma.","volume":"132","author":"Higgins RA","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800650"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00280.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01227.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02675.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018263"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6254"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.11.1055"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80864-7"},{"key":"e_1_2_5_25_2","first-page":"79","article-title":"Cutaneous manifestations of Hodgkin's disease.","volume":"32","author":"Arroyo A","year":"1983","journal-title":"Cutis"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00680.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1309\/R2Q9CCUVTLRYCF3H"},{"key":"e_1_2_5_28_2","volume-title":"Lymph nodes.","author":"Weiss LM.","year":"2008"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.4"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03462.x"},{"key":"e_1_2_5_31_2","first-page":"416.","article-title":"The pattern of CD15, CD30 and Bcl\u20102 expression in diffuse large B\u2010cell lymphoma.","volume":"61","author":"Eow GI","year":"2006","journal-title":"Med J Malaysia"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-009-0039-7"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00451.x"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204233261704"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70141-4"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07346.x"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb00743.x"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP6GR8BDEXPKHR"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2012.01872.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2012.01872.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T11:50:15Z","timestamp":1698753015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2012.01872.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,11]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1600-0560.2012.01872.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2012.01872.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,11]]}}}